Lack of Association of Bone Morphogenetic Protein 2 Gene Haplotypes with Bone Mineral Density, Bone Loss, or Risk of Fractures in Men
Table 4
BMP2 SNP3 genotypes and age, weight, height, BMD and annualised bone loss in male controls and men with osteoporosis.
Control
Control
Control
Patients
Patients
Patients
AA ()
AT ()
TT ()
AA ()
AT ()
TT ()
Age (yr)
66.1 (7.2)
64.0 (9.4)
65.4 (7.4)
65.7 (9.2)
59.0 (12.6)
57.1 (12.9)
Height (cm)
173 (7)
173 (7)
172 (5)
174 (9)
172 (8)
171 (7)
Weight (kg)
81.9 (9.6)
80.8 (12.4)
81.2 (12.5)
83.9 (25.9)
75.7 (11.8)
74.0 (14)
Spinal BMD (g/cm2)
1.132 (0.195)
1.112 (0.156)
1.105 (0.152)
0.826 (0.058)
0.785 (0.095)
0.807 (0.113)
Spinal Z score
1.15 (1.85)
0.92 (1.46)
0.93 (1.38)
−1.71 (0.55)
−2.16 (0.88)
−2.03 (1.13)
Spinal T score
0.14 (1.46)
0.14 (1.46)
0.14 (1.46)
−2.43 (0.50)
−2.81 (0.86)
−2.60 (1.03)
Total femoral BMD (g/cm2)
1.012 (0.133)
1.014 (0.119)
1.039 (0.135)
0.821 (0.121)
0.782 (0.091)
0.773 (0.114)
Total femoral Z score
0.65 (1.04)
0.64 (0.90)
0.86 (1.01)
−0.91 (0.77)
−1.24 (0.79)
−1.39 (0.87)
Total femoral T score
−0.39 (1.03)
−0.37 (0.93)
−0.21 (1.05)
−1.91 (0.95)
−2.19 (0.68)
−2.28 (0.83)
Femoral neck BMD (g/cm2)
0.860 (0.132)
0.840 (0.132)
0.861 (0.125)
0.708 (0.095)
0.687 (0.087)
0.695 (0.114)
Femoral neck Z score
0.82 (1.24)
0.59 (1.03)
0.85 (1.10)
−0.74 (0.67)
−1.07 (0.87)
−1.10 (1.00)
Femoral neck T score
−0.39 (1.03)
−0.37 (0.93)
−0.20 (1.05)
−2.42 (0.87)
−2.62 (.076)
−2.54 (1.00)
Spinal bone loss (% per annum)
−0.37 (1.14)
−0.51 (1.47)
−0.45 (1.05)
()
()
()
Femoral neck bone loss (% per annum)
−0.03 (1.77)
0.20 (1.59)
0.33 (1.42)
()
()
()
Total femoral bone loss (% per annum)
0.00 (0.80)
0.16 (1.70)
0.15 (1.07)
()
()
()
No significant effect of BMP2 genotypes on height, weight or BMD was seen using ANOVA (). Annualized loss was studied in a subgroups of subjects, the numbers indicated in appropriate cells. Results are given as mean, and SDs are given in parentheses.
