Journal of Osteoporosis / 2011 / Article / Tab 4 / Research Article
The Evidence for Efficacy of Osteoporosis Treatment in Men with Primary Osteoporosis: A Systematic Review and Meta-Analysis of Antiresorptive and Anabolic Treatment in Men Study General (
(%)) Specific (
(%)) Any AE Any serious AE Death Withdrawals due to AE Alendronate Placebo Alendronate
Orwollet al. [27 ] Placebo 22 (23) 10 (11) Any upper GI AE 21 (22) 37 (25) Alendronate
27 (18)
4 (3) Dyspepsia 1 (1) 9 (6) Abdominal pain 4 (4) 12 (8) Esophagitis 1 (1) 1 (1) Reflux 5 (5) 7 (5)
Gonnelli et al. [28 ]
Placebo Alendronate
NA
NA Risedronate Placebo Risedronate
Boonen et al. [29 ]
Placebo
68 (73)
15 (16)
3 (3)
9 (9.7) Any upper GI AE 17 (18) 16 (8) Constipation 5 (5) 16 (8) Risedronate
134 (70)
29 (15)
2 (1)
7 (3.7) Back pain 2 (2) 13 (7) Arthralgia 8 (9) 11 (6) Influenza 5 (5) 11 (6) Nasopharyngitis 5 (5) 11 (6) Headache 0 (0) 10 (5) Ibandronate Placebo Ibandronate
Orwoll et al. [30 ] Placebo 4 (9) (7) 2 Any 4 (9) 16 (19) Ibandronate 16 (19) (9) 1 Abdominal pain (0) (3) Miacakcic
Owroll et al. [30 ] Placebo Miacalcic Very well tolerated and no significant side effects 0 0 NA Teriparatide Placebo Teriparatide Teriparatide
Trovas et al. [31 ]
Placebo
39 patients
3
0
7
Nausea Headache
3.4 NA
5.3 N A
18.7 10. 8 Teriparatide 20 μ g withdrew due to 3 2 14 Teriparatide 40 μ g side-effects 0 0 18
Orwoll et al. [32 ] Teriparatide 0 0 0 Hypercalcemia 0 2 Placebo 0 0 0 Redness at inj. site 0 5