Inhibition of Bone Loss by Cissus quadrangularis in Mice: A Preliminary Report

Table 2

Effects of Cissus quadrangularis on the Biochemical markers of bone turnover, pro-inflammatory cytokines and leptin in the serum of female ovariectomized C57BL/6 mice.

Parameters/Groups	LC Sham	LC OVX	% difference (LC Sham versus LC OVX)	CQ Sham	CQ OVX	% difference (CQ Sham versus CQ OVX)
P1NP (ng/mL)	13.23 ± 1.17^a	10.44 ± 0.18	21↓	7.29 ± 0.85^b	6.55 ± 0.57	10↓
Alkaline phosphatase (U/L)	1.95 ± 0.24^a	0.93 ± 0.18	48↓	1.60 ± 0.09	2.09 ± 0.57	6
Osteocalcin (ng/mL)	45.78 ± 1.11	51.82 ± 7.74		40.45 ± 2.27	34.53 ± 4.49
Trap5b (U/L)	13.53 ± 0.87	12.39 ± 0.65		12.92 ± 0.56	13.23 ± 1.46
IL-1𝛽 (pg/mL)	418 ± 143	580 ± 127	39↑	66 ± 8^b	278 ± 30^d	322^∗↑
IL-6 (pg/mL)	818 ± 152	888 ± 202	9↑	387 ± 35^b	547 ± 77^a	41↑
TNF-α(pg/mL)	1.47 ± 0.43	2.12 ± 0.45	44↑	0.76 ± 0.21	0.69 ± 0.08^a	13↓
Leptin (pg/mL)	169 ± 27^a	1100 ± 85	550↑	621 ± 115^b	1321 ± 147^c	112↑

Data are Mean ± SE. ^a𝑃<0.05 versus LC O; ^b𝑃<0.05 versus LC S; ^c𝑃<0.05 versus CQ S; ^d𝑃<0.08 versus LC O; ^*= 𝑃<0.05 versus LC; ↑: increase; ↓: decrease.