Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats

Table 1

Maximum load (N) at 9 and 12 months.

Group	Maximum Load
	9 months			12 months
	Animal	Measurement (N)	Mean ± SD	Animal	Measurement (N)	Mean ± SD
ODW	1	134.5	124.2 ± 12.1	11	119.1	112.6 ± 8.9
	2	111.4		12	95.4
	3	105.8		13	111.5
	4	110.5		14	113.1
	5	133.2		15	116.8
	6	137.1		16	120.5
	7	135.4		17	124.2
	8	125.1		18	107.5
	9	115.7		19	101.7
	10	133.1		20	116.3
OZA	31	128.8	141.4 ± 9.8	21	125.4	138.7 ± 9.1
	32	133.2		22	131.7
	33	152.5		23	147.2
	34	151.7		24	149.3
	35	137.0		25	133.1
	36	137.4		26	135.8
	37	158.4		27	153.0
	38	139.0		28	140.7
	39	132.8		29	129.4
	40	143.0		30	141.2
SDW	41	126.0	140.0 ± 6.6	51	109.0	118.4 ± 10.5
	42	138.9		52	111.0
	43	149.4		53	125.5
	44	135.7		54	110.3
	45	141.4		55	116.8
	46	136.8		56	110.6
	47	147.1		57	124.1
	48	144.2		58	140.9
	49	138.4		59	109.7
	50	142.0		60	126.3
SZA	71	142.5	149.7 ± 4.3	61	142.7	151.0 ± 9.7
	72	152.9		62	150.4
	73	151.7		63	154.1
	74	147.1		64	148.9
	75	152.8		65	137.6
	76	154.9		66	170.7
	77	149.2		67	150.2
	78	154.2		68	140.4
	79	143.7		69	158.8
	80	148.5		70	156.7