Effect of additional risk factors to predict first major osteoporotic fracture (Fx) over 10 years among Rochester, MN women and men ≥40 years of age, after adjusting for the full US FRAX (FN BMD) probability.
Model
Women (44 Fxs)
Men (18 Fxs)
HR (95% CI)a
Cb
HR (95% CI)a
Cb
Fall history in past year (y/n)
0.8 (0.5–1.6)
0.75
0.9 (0.4–2.4)
0.65
Fall risk factors (y/n)
1.5 (0.5–4.2)
0.74
2.0 (0.7–5.7)
0.64
Additional causes of secondary osteoporosis (y/n)
0.5 (0.3–0.98)
0.76
1.5 (0.6–3.9)
0.64
Concurrent estrogen use (y/n)
1.2 (0.6–2.7)
0.74
N.A.
—
Lumbar spine BMD (g/cm2) (per SD )
1.2 (0.8–1.8)
0.74
1.1 (0.6–1.8)
0.66
Femoral neck-lumbar spine T-score difference (per unit )
1.0 (0.7–1.5)
0.75
0.8 (0.5–1.1)
0.62
Serum NTxc (nMBCE) (per SD )
1.1 (0.8–1.5)
0.75
0.8 (0.4–1.5)
0.67
Serum osteocalcin (OC, ng/mL) (per SD )
1.3 (0.9–1.8)
0.76
1.0 (0.6–1.8)
0.65
NTx/OC ratio (per SD ↑)
1.4 (1.1–1.6)
0.78
1.2 (1.04–1.4)
0.66
aHazard ratio (HR) and 95% confidence interval (CI).
bConcordance (C) statistic.
cSerum cross-linked N-telopeptides of type I collagen.
