Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats

Table 2

Bone Area (BA), bone mineral content (BMC), and bone mineral density (BMD) measured in femur and in lumbar vertebra in female Wistar rats at the end of the study. Six-month-old rats at the beginning of the study, ovariectomized (OVX) or sham-operated (SHAM) were randomized in the following groups: SHAM group (SHAM), treated with vehicle for 3 months; ovariectomized group (OVX) also treated with vehicle for 3 months; ovariectomized group treated with Kalsis at a dose of 25 mg/kg/day, for 3 months (OVX + K25). Statistical significance 𝑃<0.05: a versus SHAM; b versus OVX.

	BA (cm^2)	BMC (g)	BMD (cm^2/g)
	Femoral
SHAM	1.730±0.15	0.485±0.072	0.280±0.017
OVX	1.869±0.069^a	0.474±0.074	0.263±0.011^a
OVX + K25	1.847±0.122^a	0.506±0.05	0.273±0.011^b
	Lumbar
SHAM	1.423±0.127	0.326±0.054	0.235±0.021
OVX	1.499±0.104	0.324±0.038	0.216±0.013^a
OVX + K25	1.526±0.123^a	0.347±0.053	0.227±0.017^b