Serum Dickkopf-1 Level in Postmenopausal Females: Correlation with Bone Mineral Density and Serum Biochemical Markers

Table 1

Comparison between postmenopausal females with abnormal DXA results (groups I and II) and normal DXA results (controls) regarding demographic and laboratory data.

	Groups I and II   𝑛=42		Controls   𝑛=18		𝑃  value	Sig.
	Range	Mean ± SD	Range	Mean ± SD
Age	47–52	49.95±2.9	45–51	47.77±1.8	𝑃=0.07	NS
Menopause age (yrs)	42–49	45.95±1.76	44–50	45.72±1.87	𝑃=0.66	NS
Dur. of postmenop. (yrs)	2–10	4.1±2.4	1-2	1.0±0.2	𝑃<0.001	HS
Ca (mg/dL)	8.5–10.2	9.2±0.3	8.9–10.3	9.6±0.5	𝑃=0.025	S
Ph. (mg/dL)	2.7–4.1	3.5±0.43	2.7–4.1	3.5±0.38	𝑃=0.86	NS
ALP (IU/L)	45.2–60.2	54.9±4.1	44 –60.2	54.56±5.1	𝑃=0.77	NS
DKK 1 (pg/mL)	2490–3530	2736.9±206.87	1930–2395	2218.9±148.26	𝑃<0.001	HS

Dur. of menop.: duration of menopause, Ca: calcium, Ph: phosphorus, ALP: alkaline phosphatase, DKK-1: Dickkopf, NS: nonsignificant, HS: highly significant, and S: significant.