Table of Contents Author Guidelines Submit a Manuscript
Journal of Osteoporosis
Volume 2013 (2013), Article ID 825985, 9 pages
http://dx.doi.org/10.1155/2013/825985
Research Article

Effects of Vitamin E on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats

1Nutrition, Food & Exercise Sciences, The Florida State University, Tallahassee, FL 32306, USA
2Center for Advancing Exercise and Nutrition Research on Aging, Department of Nutrition, Food and Exercise Sciences, The Florida State University, 436 Sandels Building, Tallahassee, FL 32306, USA
3Departments of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA
4Departments of Statistics, Oklahoma State University, Stillwater, OK 74078, USA
5Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA

Received 8 May 2013; Accepted 26 July 2013

Academic Editor: Carmelo E. Fiore

Copyright © 2013 Rafaela G. Feresin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Dixon, “Hormone replacement therapy and the breast,” British Medical Journal, vol. 323, no. 7326, pp. 1381–1382, 2001. View at Google Scholar · View at Scopus
  2. R. Marcus, “Post-menopausal osteoporosis,” Best Practice and Research, vol. 16, no. 3, pp. 309–327, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. P. M. Barnes, E. Powell-Griner, K. McFann, and R. L. Nahin, “Complementary and alternative medicine use among adults: United States, 2002,” Advance Data, no. 343, pp. 1–19, 2004. View at Google Scholar · View at Scopus
  4. J. J. Stepan, J. Pospichal, J. Presl, and V. Pacovsky, “Bone loss and biochemical indices of bone remodeling in surgically induced postmenopausal women,” Bone, vol. 8, no. 5, pp. 279–284, 1987. View at Google Scholar · View at Scopus
  5. L. G. Raisz, “Bone cell biology: new approaches and unanswered questions,” Journal of Bone and Mineral Research, vol. 8, supplement 2, pp. S457–S465, 1993. View at Google Scholar · View at Scopus
  6. V. K. Tam, S. Schotland, and J. Green, “Inflammatory cytokines (IL-1α, TNF-α) and LPS modulate the Ca2+ signaling pathway in osteoblasts,” American Journal of Physiology—Cell Physiology, vol. 274, no. 6, pp. C1686–C1698, 1998. View at Google Scholar · View at Scopus
  7. K. Traianedes, M. R. Dallas, I. R. Garrett, G. R. Mundy, and L. F. Bonewald, “5-lipoxygenase metabolites inhibit bone formation in vitro,” Endocrinology, vol. 139, no. 7, pp. 3178–3184, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. S. C. Manolagas, “Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis,” Endocrine Reviews, vol. 21, no. 2, pp. 115–137, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Cheleuitte, S. Mizuno, and J. Glowacki, “In vitro secretion of cytokines by human bone marrow: effects of age and estrogen status,” Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 6, pp. 2043–2051, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Walston, D. E. Arking, D. Fallin et al., “IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women,” Experimental Gerontology, vol. 40, no. 4, pp. 344–352, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. C. A. Dinarello, “Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process,” The American Journal of Clinical Nutrition, vol. 83, no. 2, pp. 447s–455s, 2006. View at Google Scholar · View at Scopus
  12. A. Bartocci, V. Papademetriou, E. Schlick, B. C. Nisula, and M. A. Chirigos, “Effect of crude and purified human chorionic gonadotropin on murine delayed-type hypersensitivity: a role for prostaglandins,” Cellular Immunology, vol. 71, no. 2, pp. 326–333, 1982. View at Google Scholar · View at Scopus
  13. S. N. Meydani, M. Meydani, C. P. Verdon, A. A. Shapiro, J. B. Blumberg, and K. C. Hayes, “Vitamin E supplementation suppresses prostaglandin E1(2) synthesis and enhances the immune response of aged mice,” Mechanisms of Ageing and Development, vol. 34, no. 2, pp. 191–201, 1986. View at Google Scholar
  14. S. N. Meydani, M. P. Barklund, S. Liu et al., “Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects,” The American Journal of Clinical Nutrition, vol. 52, no. 3, pp. 557–563, 1990. View at Google Scholar · View at Scopus
  15. G. Banfi, E. L. Iorio, and M. M. Corsi, “Oxidative stress, free radicals and bone remodeling,” Clinical Chemistry and Laboratory Medicine, vol. 46, no. 11, pp. 1550–1555, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. M. G. Hayek, S. N. Meydani, and J. B. Blumberg, “Age differences in eicosanoid production of mouse splenocytes: effects on mitogen-induced T-cell proliferation,” Journals of Gerontology, vol. 49, no. 5, pp. B197–B207, 1994. View at Google Scholar · View at Scopus
  17. M. G. Hayek, C. Mura, D. Wu et al., “Enhanced expression of inducible cyclooxygenase with age in murine macrophages,” Journal of Immunology, vol. 159, no. 5, pp. 2445–2451, 1997. View at Google Scholar · View at Scopus
  18. D. Wu, A. A. Beharka, S. N. Han et al., “Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E,” American Journal of Physiology—Cell Physiology, vol. 275, no. 3, pp. C661–C668, 1998. View at Google Scholar · View at Scopus
  19. C. F. Nathan, “Secretory products of macrophages,” The Journal of Clinical Investigation, vol. 79, no. 2, pp. 319–326, 1987. View at Google Scholar · View at Scopus
  20. G. R. Mundy, “Cytokines and growth factors in the regulation of bone remodeling,” Journal of Bone and Mineral Research, vol. 8, supplement 2, pp. S505–S510, 1993. View at Google Scholar · View at Scopus
  21. D. Harman, “Aging and oxidative stress,” The Journal of the International Federation of Clinical Chemistry, vol. 10, no. 1, pp. 24–27, 1998. View at Google Scholar · View at Scopus
  22. I. R. Garrett, B. F. Boyce, R. O. C. Oreffo, L. Bonewald, J. Poser, and G. R. Mundy, “Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo,” The Journal of Clinical Investigation, vol. 85, no. 3, pp. 632–639, 1990. View at Google Scholar · View at Scopus
  23. R. J. van't Hof and S. H. Ralston, “Nitric oxide and bone,” Immunology, vol. 103, no. 3, pp. 255–261, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Gokturk, A. Turgut, C. Baycu, I. Gunal, S. Seber, and Z. Gulbas, “Oxygen-free radicals impair fracture healing in rats,” Acta Orthopaedica Scandinavica, vol. 66, no. 5, pp. 473–475, 1995. View at Google Scholar · View at Scopus
  25. S. Basu, K. Michaëlsson, H. Olofsson, S. Johansson, and H. Melhus, “Association between oxidative stress and bone mineral density,” Biochemical and Biophysical Research Communications, vol. 288, no. 1, pp. 275–279, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. J. M. Lean, J. T. Davies, K. Fuller et al., “A crucial role for thiol antioxidants in estrogen-deficiency bone loss,” The Journal of Clinical Investigation, vol. 112, no. 6, pp. 915–923, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Muthusami, I. Ramachandran, B. Muthusamy et al., “Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats,” Clinica Chimica Acta, vol. 360, no. 1-2, pp. 81–86, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. E. J. Crary and M. F. McCarty, “Potential clinical applications for high-dose nutritional antioxidants,” Medical Hypotheses, vol. 13, no. 1, pp. 77–98, 1984. View at Google Scholar · View at Scopus
  29. A. Azzi, I. Breyer, M. Feher et al., “Specific cellular responses to α-tocopherol,” Journal of Nutrition, vol. 130, no. 7, pp. 1649–1652, 2000. View at Google Scholar · View at Scopus
  30. Y. Wang, D. S. Huang, B. Liang, and R. R. Watson, “Nutritional status and immune responses in mice with murine AIDS are normalized by vitamin E supplementation,” Journal of Nutrition, vol. 124, no. 10, pp. 2024–2032, 1994. View at Google Scholar · View at Scopus
  31. L. J. van Tits, P. N. Demacker, J. de Graaf, H. L. Hak-Lemmers, and A. F. Stalenhoef, “α-Tocopherol supplementation decreases production of superoxide and cytokines by leukocytes ex vivo in both normolipidemic and hypertriglyceridemic individuals,” The American Journal of Clinical Nutrition, vol. 71, no. 2, pp. 458–464, 2000. View at Google Scholar · View at Scopus
  32. I. Jialal, S. Devaraj, and N. Kaul, “The effect of α-Tocopherol on monocyte proatherogenic activity,” Journal of Nutrition, vol. 131, no. 2, pp. 389s–394s, 2001. View at Google Scholar · View at Scopus
  33. D. Y. Wu, M. G. Hayek, and S. N. Meydani, “Vitamin E and macrophage cyclooxygenase regulation in the aged,” Journal of Nutrition, vol. 131, no. 2, pp. 382S–288S, 2001. View at Google Scholar · View at Scopus
  34. K. Asehnoune, D. Strassheim, S. Mitra, J. Y. Kim, and E. Abraham, “Involvement of reactive oxygen species in toll-like receptor 4-dependent activation of NF-κB,” Journal of Immunology, vol. 172, no. 4, pp. 2522–2529, 2004. View at Google Scholar · View at Scopus
  35. S. C. Manolagas and R. L. Jilka, “Mechanisms of disease: bone marrow, cytokines, and bone remodeling—emerging insights into the pathophysiology of osteoporosis,” The New England Journal of Medicine, vol. 332, no. 5, pp. 305–311, 1995. View at Publisher · View at Google Scholar · View at Scopus
  36. R. Ricciarelli, J.-M. Zingg, and A. Azzi, “Vitamin E: protective role of a Janus molecule,” The FASEB Journal, vol. 15, no. 13, pp. 2314–2325, 2001. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Xu, B. A. Watkins, and M. F. Seifert, “Vitamin E stimulates trabecular bone formation and alters epiphyseal cartilage morphometry,” Calcified Tissue International, vol. 57, no. 4, pp. 293–300, 1995. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Durak, Ö. F. Bilgen, T. Kaleli, P. Tuncel, R. Özbek, and K. Turan, “Antioxidant effect of α-tocopherol on fracture haematoma in rabbits,” Journal of International Medical Research, vol. 24, no. 5, pp. 419–424, 1996. View at Google Scholar · View at Scopus
  39. A. N. Shuid, S. Mohamad, N. Muhammad, S. Afian Mokhtar, N. Muhammad, and I. Nirwana Soelaiman, “Bone oxidative changes during early fracture healing of postmenopausal osteoporosis rat model,” Asian Journal of Animal and Veterinary Advances, vol. 6, no. 12, pp. 1193–1203, 2011. View at Google Scholar
  40. A. N. Shuid, S. Mohamad, N. Muhammad et al., “Effects of α-tocopherol on the early phase of osteoporotic fracture healing,” Journal of Orthopaedic Research, vol. 29, no. 11, pp. 1732–1738, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Mohamad, A. Shuid, N. Mohamed, F. Fadzilah, S. Mokhtar, S. Abdullah et al., “The effects of alpha-tocopherol supplementation on fracture healing in a postmenopausal osteoporotic rat model,” Clinics, vol. 67, no. 9, pp. 1077–1085, 2012. View at Google Scholar
  42. C. Y. Turk, M. Halici, A. Guney, H. Akgun, V. Sahin, and S. Muhtaroglu, “Promotion of fracture healing by vitamin E in rats,” Journal of International Medical Research, vol. 32, no. 5, pp. 507–512, 2004. View at Google Scholar · View at Scopus
  43. H. Melhus, K. Michaëlsson, L. Holmberg, A. Wolk, and S. Ljunghall, “Smoking, antioxidant vitamins, and the risk of hip fracture,” Journal of Bone and Mineral Research, vol. 14, no. 1, pp. 129–135, 1999. View at Publisher · View at Google Scholar · View at Scopus
  44. M. S. Hamidi, P. N. Corey, and A. M. Cheung, “Effects of vitamin E on bone turnover markers among US postmenopausal women,” Journal of Bone and Mineral Research, vol. 27, no. 6, pp. 1368–1380, 2012. View at Google Scholar
  45. B. H. Arjmandi, S. Juma, A. Beharka, M. S. Bapna, M. Akhter, and S. N. Meydani, “Vitamin E improves bone quality in the aged but not in young adult male mice,” The Journal of Nutritional Biochemistry, vol. 13, no. 9, pp. 543–549, 2002. View at Publisher · View at Google Scholar · View at Scopus
  46. S. C. Chai, C.-I. Wei, K. Brummel-Smith, and B. H. Arjmandi, “The role of vitamin E in reversing bone loss,” Aging, vol. 20, no. 6, pp. 521–527, 2008. View at Google Scholar · View at Scopus
  47. B. J. Smith, E. A. Lucas, R. T. Turner et al., “Vitamin E provides protection for bone in mature hindlimb unloaded male rats,” Calcified Tissue International, vol. 76, no. 4, pp. 272–279, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Norazlina, S. Ima-Nirwana, M. T. Gapor, and B. A. K. Khalid, “Palm vitamin E is comparable to α-tocopherol in maintaining bone mineral density in ovariectomised female rats,” Experimental and Clinical Endocrinology and Diabetes, vol. 108, no. 4, pp. 305–310, 2000. View at Publisher · View at Google Scholar · View at Scopus
  49. B. H. Arjmandi, M. J. Getlinger, N. V. Goyal et al., “Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats,” The American Journal of Clinical Nutrition, vol. 68, supplement 6, pp. 1358S–1363S, 1998. View at Google Scholar · View at Scopus
  50. J. G. Bieri, T. J. Tolliver, and G. L. Catignani, “Simultaneous determination of α-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography,” The American Journal of Clinical Nutrition, vol. 32, no. 10, pp. 2143–2149, 1979. View at Google Scholar · View at Scopus
  51. M. P. Akhter, U. T. Iwaniec, G. R. Haynatzki, Y. K. Fung, D. M. Cullen, and R. R. Recker, “Effects of nicotine on bone mass and strength in aged female rats,” Journal of Orthopaedic Research, vol. 21, no. 1, pp. 14–19, 2003. View at Publisher · View at Google Scholar · View at Scopus
  52. R. D. Wasnich, P. D. Ross, L. K. Heilbrun, and J. M. Vogel, “Prediction of postmenopausal fracture risk with use of bone mineral measurements,” The American Journal of Obstetrics and Gynecology, vol. 153, no. 7, pp. 745–751, 1985. View at Google Scholar · View at Scopus
  53. J. A. Kanis, “Osteoporosis III: diagnosis of osteoporosis and assessment of fracture risk,” The Lancet, vol. 359, no. 9321, pp. 1929–1936, 2002. View at Publisher · View at Google Scholar · View at Scopus
  54. D. R. Taaffe, T. F. Lang, and T. B. Harris, “Poor correlation of mid-femoral measurements by CT and hip measurements by DXA in the elderly,” Aging, vol. 15, no. 2, pp. 131–135, 2003. View at Google Scholar · View at Scopus
  55. G. M. Wardlaw, “Putting osteoporosis in perspective,” Journal of the American Dietetic Association, vol. 93, no. 9, pp. 1000–1006, 1993. View at Publisher · View at Google Scholar · View at Scopus
  56. P. D. Delmas, “Treatment of postmenopausal osteoporosis,” The Lancet, vol. 359, no. 9322, pp. 2018–2026, 2002. View at Publisher · View at Google Scholar · View at Scopus
  57. B. H. Arjmandi, M. Akhter, D. Chakkalakal et al., “Effects of isoflavones, vitamin E, and their combination on bone in an aged rat model of osteopenia,” Journal of Bone and Mineral Research, vol. 16, supplement 1, p. s533, 2001. View at Google Scholar
  58. A. N. Shuid, Z. Mehat, N. Mohamed, N. Muhammad, and I. N. Soelaiman, “Vitamin E exhibits bone anabolic actions in normal male rats,” Journal of Bone and Mineral Metabolism, vol. 28, no. 2, pp. 149–156, 2010. View at Publisher · View at Google Scholar · View at Scopus
  59. M. G. Traber and H. Sies, “Vitamin E in humans: demand and delivery,” Annual Review of Nutrition, vol. 16, pp. 321–347, 1996. View at Google Scholar · View at Scopus
  60. M. Schultz, M. Leist, M. Petrzika, B. Gassmann, and R. Brigelius-Flohe, “Novel urinary metabolite of α-tocopherol, 2,5,7,8-tetramethyl-2(2′- carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?” The American Journal of Clinical Nutrition, vol. 62, no. 6, pp. S1527–S1534, 1995. View at Google Scholar · View at Scopus
  61. I. Jialal, C. J. Fuller, and B. A. Huet, “The effect of α-tocopherol supplementation on LDL oxidation. A dose-response study,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 15, no. 2, pp. 190–198, 1995. View at Google Scholar · View at Scopus
  62. D. H. Blatt, S. W. Leonard, and M. G. Traber, “Vitamin E kinetics and the function of tocopherol regulatory proteins,” Nutrition, vol. 17, no. 10, pp. 799–805, 2001. View at Publisher · View at Google Scholar · View at Scopus
  63. K. Fujita, M. Iwasaki, H. Ochi et al., “Vitamin E decreases bone mass by stimulating osteoclast fusion,” Nature Medicine, vol. 18, no. 4, pp. 589–594, 2012. View at Publisher · View at Google Scholar · View at Scopus
  64. H. Hermizi, O. Faizah, S. Ima-Nirwana, S. Ahmad Nazrun, and M. Norazlina, “Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in Sprague-Dawley male rats after nicotine cessation,” Calcified Tissue International, vol. 84, no. 1, pp. 65–74, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. N. S. Ahmad, B. A. K. Khalid, D. A. Luke, and S. I. Nirwana, “Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone,” Clinical and Experimental Pharmacology and Physiology, vol. 32, no. 9, pp. 761–770, 2005. View at Publisher · View at Google Scholar · View at Scopus
  66. M. Z. Mehat, A. N. Shuid, N. Mohamed, N. Muhammad, and I. N. Soelaiman, “Beneficial effects of vitamin E isomer supplementation on static and dynamic bone histomorphometry parameters in normal male rats,” Journal of Bone and Mineral Metabolism, vol. 28, no. 5, pp. 503–509, 2010. View at Publisher · View at Google Scholar · View at Scopus
  67. M. Meydani, “Vitamin E and atherosclerosis: beyond prevention of LDL oxidation,” Journal of Nutrition, vol. 131, no. 2, pp. 366S–368S, 2001. View at Google Scholar · View at Scopus
  68. S. C. Chai and B. H. Arjmandi, “Vitamin E dose-dependently reduces aortic fatty lesion formation in orchidectomized aged rats,” Aging, vol. 23, no. 1, pp. 11–16, 2011. View at Publisher · View at Google Scholar · View at Scopus
  69. A. Dutta and S. K. Dutta, “Vitamin E and its role in the prevention of atherosclerosis and carcinogenesis: a review,” Journal of the American College of Nutrition, vol. 22, no. 4, pp. 258–268, 2003. View at Google Scholar · View at Scopus
  70. D. Wu, M. G. Hayek, and S. Meydani, “Vitamin E and macrophage cyclooxygenase regulation in the aged,” Journal of Nutrition, vol. 131, no. 2, pp. 382S–388S, 2001. View at Google Scholar · View at Scopus
  71. A. A. Beharka, D. Wu, S. N. Han, and S. N. Meydani, “Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E,” Mechanisms of Ageing and Development, vol. 93, no. 1–3, pp. 59–77, 1997. View at Publisher · View at Google Scholar · View at Scopus
  72. D. Y. Wu, M. Meydani, A. A. Beharka, M. Serafini, K. R. Martin, and S. N. Meydani, “In vitro supplementation with different tocopherol homologues can affect the function of immune cells in old mice,” Free Radical Biology and Medicine, vol. 28, no. 4, pp. 643–651, 2000. View at Publisher · View at Google Scholar · View at Scopus
  73. J. Pfeilschifter, R. Köditz, M. Pfohl, and H. Schatz, “Changes in proinflammatory cytokine activity after menopause,” Endocrine Reviews, vol. 23, no. 1, pp. 90–119, 2002. View at Publisher · View at Google Scholar · View at Scopus
  74. A. A. Beharka, S. N. Han, O. Adolfsson et al., “Long-term dietary antioxidant supplementation reduces production of selected inflammatory mediators by murine macrophages,” Nutrition Research, vol. 20, no. 2, pp. 281–296, 2000. View at Publisher · View at Google Scholar · View at Scopus