Research Article
Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates
Table 2
Comparisons of mean disintegration times among brand and generic bisphosphonates.
| Bisphosphonate tablet comparison | Mean disintegration time difference in seconds | 95% CIa |
| Brand alendronate—brand alendronate plus vitamin D | −231* | 264, 197 | Brand alendronate—risedronate | 46* | 13, 80 | Brand alendronate—Apo-alendronate | 122* | 88, 155 | Brand alendronate—Novo-alendronate | 135* | 100, 169 | Brand alendronate plus vitamin D—risedronate | 277* | 243, 310 | Brand alendronate plus vitamin D—Apo-alendronate | 352* | 319, 386 | Brand alendronate plus vitamin D—Novo-alendronate | 365* | 331, 400 | Risedronate—Apo-alendronate | 76* | 42, 109 | Risedronate—Novo-alendronate | 89* | 54, 123 | Apo-alendronate—Novo-alendronate | 13 | −20, 46 |
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95% CI = 95% confidence interval; significant disintegration time difference between groups at .
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