Journal of Osteoporosis / 2014 / Article / Tab 2

Research Article

Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates

Table 2

Comparisons of mean disintegration times among brand and generic bisphosphonates.

Bisphosphonate tablet comparisonMean disintegration time difference in seconds95% CIa

Brand alendronate—brand alendronate plus vitamin D−231*264, 197
Brand alendronate—risedronate46*13, 80
Brand alendronate—Apo-alendronate122*88, 155
Brand alendronate—Novo-alendronate135*100, 169
Brand alendronate plus vitamin D—risedronate277*243, 310
Brand alendronate plus vitamin D—Apo-alendronate352*319, 386
Brand alendronate plus vitamin D—Novo-alendronate365*331, 400
Risedronate—Apo-alendronate76*42, 109
Risedronate—Novo-alendronate89*54, 123
Apo-alendronate—Novo-alendronate13−20, 46

95% CI = 95% confidence interval; significant disintegration time difference between groups at .

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