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Journal of Osteoporosis
Volume 2014, Article ID 468397, 9 pages
Clinical Study

Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional Study

1Clinical Pharmacy Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254, Saudi Arabia
2Clinical Pharmacy Department, Faculty of Pharmacy, Umm Al-Qura University, Makkah 24243, Saudi Arabia
3King Abdullah Medical City, Makkah 24246, Saudi Arabia
4Center of Excellence for Osteoporosis Research, King Abdulaziz University, Jeddah 22254, Saudi Arabia

Received 24 February 2014; Revised 21 July 2014; Accepted 21 July 2014; Published 13 August 2014

Academic Editor: Salvatore Minisola

Copyright © 2014 Abrar Thabit et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Besides lipid-lowering effect of statins, they have been shown to have nonlipid lowering effects, such as improving bone health. An improvement in bone mineral density (BMD) has been indicated in some studies after the use of statins, in addition to an increase in 25-hydroxyvitamin D (25OHD) level. The aim of this study is to explore the association between statins and bone health taking into consideration 25OHD level and BMD. Methods. This is a randomized, cross-sectional comparative study. Subjects were divided into two groups, hypercholesterolemic participants taking simvastatin or atorvastatin as the study group and a matched control group not taking statins. All participants were assessed for serum 25OHD and BMD at lumbar spine and femoral neck. Results. A total of 114 participants were included in the study, 57 participants in each group. Results of serum 25OHD showed no significant difference between study and control groups (), while BMD results of lumbar spine and femoral neck showed significant difference ( and 0.03, resp.). Conclusion. Simvastatin and atorvastatin, at any dose for duration of more than one year, have no additive effect on 25OHD level but have a positive effect on the BMD.