Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D₂ (300,000 IU)

Table 3

Multilinear regression analysis of the % change in the Wnt inhibitors, sclerostin and DKK1 as dependent variable and % change in 1,25 (OH)₂ vitamin D as independent variable, following correction for age, gender, and BMD. Highlighted bold is the significant variables. Dependent variable: combined % change in DKK1 and sclerostin.

Variables	-coefficients	value	value
Age	0.404	1.524	0.151
Gender	0.161	0.590	0.565
BMI	0.155	0.535	0.602
BMD lumbar spine	0.175	0.622	0.545
BMD total hip	−0.127	−0.301	0.768
Baseline GFR	0.154	0.524	0.609
% change in 1,25 (OH)2 vitamin D	0.611	2.306	0.038
% change in PTH	−0.293	−1.054	0.311
% change in 25 (OH) vitamin D	−0.491	−1.654	0.122