Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model

Table 2

Linear regression models with correlation coefficient , value, slope coefficient , and its standard error as well bootstrap derived standard error and value of (i) MRS-based proton density fat fraction with normalized failure load (norm. FL), BMD, and trabecular microstructure parameters and (ii) normalized failure load (norm. FL) with MRS-based proton density fat fraction, BMD, and trabecular microstructure parameters.

	Norm. FL	Fat fraction	BMD	BV/TV	TbN	FD
Fat fraction
	−0.77		−0.72	−0.64	−0.62	−0.36
value	0.009		0.019	0.047	0.059	0.314
Coefficient	−3687		−0.001	−0.309	−0.296	−0.276
Standard error	1082		<0.001	0.132	0.134	0.257
Bootstrap standard error	1300		<0.001	0.112	0.145	0.187
Bootstrap value	0.013		0.045	0.062	0.063	0.086
Norm. FL
		−0.77	0.90	0.88	0.89	0.83
value		0.009	<0.001	0.001	0.001	0.003
Coefficient		−3687	6.559	2056	2045	3111
Standard error		1082	1.156	386	380	730
Bootstrap standard error		1300	1.001	405	427	619
Bootstrap value		0.013	0.002	0.007	0.005	0.005