| | Rank | Paper | Absolute number of citations | Citation density | Level of evidence |
| | 1 | D. L. Lacey, E. Timms, and H. L. Tan, M. J. Kelley, C. R. Dunstan, T. Burgess, R. Elliott, A. Colombero, G. Elliott, S. Scully, H. Hsu, J. Sullivan, N. Hawkins, E. Davy, C. Capparelli, A. Eli, Y. X. Qian, S. Kaufman, I. Sarosi, V. Shalhoub, G. Senaldi, J. Guo, J. Delaney, and W. J. Boyle, “Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation,” Cell, vol. 93, pp. 165–176, 1998. | 2768 | 184,5 | N/A |
| | 2 | W. J. Boyle, W. S. Simonet, and D. L. Lacey, “Osteoclast differentiation and activation,” Cell, vol. 423, pp. 337–342, 2003. | 1651 | 165,1 | N/A |
| | 3 | W. S. Simonet, D. L. Lacey, C. R. Dunstan, M. Kelley, M. S. Chang, R. Luthy, H. Q. Nguyen, S. Wooden, L. Bennett, T. Boone, G. Shimamoto, M. DeRose, R. Elliott, A. Colombero, H. L. Tan, G. Trail, J. Sullivan, E. Davy, N. Bucay, L. Renshaw Gegg, T. M. Hughes, D. Hill, W. Pattison, P. Campbell, S. Sander, G. Van, J. Tarpley, P. Derby, R. Lee, and W. J. Boyle, Cell, vol. 89, pp. 309–319, 1997. | 2629 | 164,3 | N/A |
| | 4 | H. Yasuda, N. Shima, N. Nakagawa, K. Yamaguchi, M. Kinosaki, S. Mochizuki, A. Tomoyasu, K. Yano, M. Goto, A. Murakami, E. Tsuda, T. Morinaga, K. Higashio, N. Udagawa, N. Takahashi, and T. Suda, “Osteoclast differentiation factor is a ligand for osteoprotegerin osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, pp. 3597–3602, 1998. | 2206 | 147 | N/A |
| | 5 | T. Komori, H. Yagi, S. Nomura, A. Yamaguchi, K. Sasaki, K. Sasaki, K. Deguchi, Y. Shimizu, R. T. Bronson, Y. H. Gao, M. Inada, M. Sato, R. Okamoto, Y. Kitamura, S. Yoshiki, and T. Kishimoto, “Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to aturational arrest of osteoblasts,” Cell, vol. 89, pp. 755–764, 1998. | 2132 | 133,2 | N/A |
| | 6 | Y. Y. Kong, H. Yoshida, I. Sarosi, H. L. Tan, E. Timms, C. Capparelli, S. Morony, A. J. Oliveira-dos-Santos, G. Van, A. Itie, W. Khoo, A. Wakeham, C. R. Dunstan, D. L. Lacey, T. W. Mak, W. J. Boyle, and J. M. Penninger, “OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis,” Nature, vol. 397, pp. 315–323, 1999. | 1741 | 124,3 | N/A |
| | 7 | B. Ettinger, D. M. Black, B. H. Mitlak, R. K. Knickerbocker, T. Nickelsen, H. K. Genant, C. Christiansen, P. D. Delmas, J. R. Zanchetta, J. Stakkestad, C. C. Gluer, K. Krueger, F. J. Cohen, S. Eckert, K. E. Ensrud, L. V. Avioli, P. Lips, and S. R. Cummings, “Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene,” The Journal of the American Medical Association, vol. 282, pp. 637–645, 1999. | 1732 | 123,7 | I |
| | 8 | D. M. Black, S. R. Cummings, D. B. Karpf, J. A. Cauley, D. E. Thompson, M. C. Nevitt, D. C. Bauer, H. K. Genant, W. L. Haskell, R. Marcus, S. M. Ott, J. C. Torner, S. A. Quandt, T. F. Reiss, and K. E. Ensrud, “Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures,” Lancet, vol. 348, pp. 1535–1541, 1996. | 2067 | 121,5 | I |
| | 9 | S. R. Cummings, M. C. Nevitt, W. S. Browner, K. Stone, K. M. Fox, K. E. Ensrud, J. C. Cauley, D. Black, and T. M. Vogt, “Risk-factors for hip fracture in white women,” The New England Journal of Medicine, vol. 332, pp. 767–773, 1995. | 2102 | 116,7 | I |
| | 10 | J. M. Wozney, V. Rosen, A. J. Celeste, and L. M. Mitsock, “Novel regulators of bone-formation - molecular clones and activities,” Science, vol. 242, pp. 528–1534, 1988. | 2662 | 106,4 | N/A |
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