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Journal of Osteoporosis
Volume 2016, Article ID 1426279, 7 pages
Review Article

An Evaluative History of Bisphosphonate Drugs: Dual Physiologic Effects of Pyrophosphate as Inspiration for a Novel Pharmaceutical Class

1Markle & Hinshaw Gynecology and Harris Regional Hospital, 7190 Ellijay Road, Franklin, NC 28734, USA
2Eli Lilly and The Indiana EPA, 10113 Partridge Place, Carmel, IN 56033, USA

Received 28 August 2016; Accepted 15 September 2016

Academic Editor: George P. Lyritis

Copyright © 2016 W. Banks Hinshaw and Allyn F. DeLong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The documented history of the development of the bisphosphonate drugs is reviewed in sufficient detail to permit independent evaluation of the consistency of the conclusions reached from the available data. The evidence developed during the early interval of these studies 1960–1975 was sufficient to establish that pyrophosphate shares the subsequently established dual bisphosphonate characteristics of bone resorption inhibition and prevention of tissue mineralization.