Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status

Table 2

Bone mineral density in the lower limb regions, spine, and femoral neck in patients with coeliac disease compared with controls.

Region	Control BMD (g/cm^2) ()	Coeliac BMD (g/cm^2) ()	Coeliac score	score^†	with Bonferroni correction	Effect size Cohen	Number of coeliac patients with negative score
1				0.0001	0.0006	1.13	23
2				ns	—	0.45	21
3				0.02	0.12	0.51	21
4				0.0004	0.0024	0.95	22
5				0.1134	—	0.5	21
6				0.0001	0.0006	1.22	23
Lumbar spine				ns	na	0.35	19
Femoral neck				0.038	na	0.51	20

Control BMD refers to average across whole age range 38–77 yr. ^†Probability of coeliac score being less than zero (one-sample -test). ns: not significant. na: not applied. Control data are from [18, 19]. Effect size is an indication of how great the difference is between 2 measurements and is independent of sample size. Above 0.8 indicates a large difference, above 0.5 a medium difference, and below 0.5 a small difference.