Table of Contents Author Guidelines Submit a Manuscript
Journal of Osteoporosis
Volume 2017, Article ID 7910432, 10 pages
https://doi.org/10.1155/2017/7910432
Research Article

Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner

1Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel
2Department of Oral Biology, School of Dental Medicine, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel

Correspondence should be addressed to Uri Nevo; li.ca.uat@iruoven

Received 1 December 2016; Revised 15 March 2017; Accepted 3 May 2017; Published 30 May 2017

Academic Editor: Merry Jo Oursler

Copyright © 2017 Inbar Hillel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. E. Fisher, G. A. Rodan, and A. A. Reszka, “In vivo effects of bisphosphonates on the osteoclast mevalonate pathway,” Endocrinology, vol. 141, no. 12, pp. 4793–4796, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Canalis, A. Giustina, and J. P. Bilezikian, “Mechanisms of anabolic therapies for osteoporosis,” The New England Journal of Medicine, vol. 357, no. 9, pp. 950–916, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Yang, X. Luo, X. Xie et al., “Influences of teriparatide administration on marrow fat content in postmenopausal osteopenic women using MR spectroscopy,” Climacteric, vol. 19, no. 3, pp. 285–291, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Justesen, K. Stenderup, E. N. Ebbesen, L. Mosekilde, T. Steiniche, and M. Kassem, “Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis,” Biogerontology, vol. 2, no. 3, pp. 165–171, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Wang, H. Meng, X. Wang, C. Zhao, J. Peng, and Y. Wang, “Differentiation of bone marrow mesenchymal stem cells in osteoblasts and adipocytes and its role in treatment of osteoporosis,” Medical Science Monitor, vol. 22, pp. 226–233, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Brunner, M. Zaruba, B. Huber et al., “Parathyroid hormone effectively induces mobilization of progenitor cells without depletion of bone marrow,” Experimental Hematology, vol. 36, no. 9, pp. 1157–1166, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Lu, Q. Wang, Y. Han, J. Li, X.-J. Yang, and D. Miao, “Parathyroid hormone administration improves bone marrow microenvironment and partially rescues haematopoietic defects in Bmi1-null mice,” PLoS ONE, vol. 9, no. 4, Article ID e93864, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. V. F. Moça Trevisani, R. Riera, A. M. Imoto, H. Saconato, and Á. N. Atallah, “Teriparatide (recombinant human parathyroid hormone 1-34) in postmenopausal women with osteoporosis: systematic review,” Sao Paulo Medical Journal, vol. 126, no. 5, pp. 279–284, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. J. E. M. Brouwers, B. Van Rietbergen, R. Huiskes, and K. Ito, “Effects of PTH treatment on tibial bone of ovariectomized rats assessed by in vivo micro-CT,” Osteoporosis International, vol. 20, no. 11, pp. 1823–1835, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. E. Compston, “Prevention and management of osteoporosis. Current trends and future prospects,” Drugs, vol. 53, no. 5, pp. 727–735, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. J. a. Kanis, “Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report,” Osteoporosis International, vol. 4, no. 6, pp. 368–381, 1994. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Majumdar, H. K. Genant, S. Grampp et al., “Correlation of trabecular bone structure with age, bone mineral density, and osteoporotic status: in vivo studies in the distal radius using high resolution magnetic resonance imaging,” Journal of Bone and Mineral Research, vol. 12, no. 1, pp. 111–118, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. T. M. Link, S. Majumdar, S. Grampp et al., “Imaging of trabecular bone structure in osteoporosis,” European Radiology, vol. 9, no. 9, pp. 1781–1788, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. T. G. Maris, J. Damilakis, L. Sideri et al., “Assessment of the skeletal status by MR relaxometry techniques of the lumbar spine: comparison with dual X-ray absorptiometry,” European Journal of Radiology, vol. 50, no. 3, pp. 245–256, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. F. W. Wehrli, J. A. Hopkins, S. N. Hwang, H. K. Song, P. J. Snyder, and J. G. Haddad, “Cross-sectional study of osteopenia with quantitative MR imaging and bone densitometry,” Radiology, vol. 217, no. 2, pp. 527–538, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. J. F. Griffith, D. K. W. Yeung, G. E. Antonio et al., “Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation,” Radiology, vol. 241, no. 3, pp. 831–838, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. D. K. W. Yeung, S. Y. S. Wong, J. F. Griffith, and E. M. C. Lau, “Bone marrow diffusion in osteoporosis: evaluation with quantitative MR diffusion imaging,” Journal of Magnetic Resonance Imaging, vol. 19, no. 2, pp. 222–228, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Blümich, J. Perlo, and F. Casanova, “Mobile single-sided NMR,” Progress in Nuclear Magnetic Resonance Spectroscopy, vol. 52, no. 4, pp. 197–269, May 2008. View at Google Scholar
  19. M. V. Landeghem, E. Danieli, J. Perlo, B. Blümich, and F. Casanova, “Low-gradient single-sided NMR sensor for one-shot profiling of human skin,” Journal of Magnetic Resonance, vol. 215, pp. 74–84, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Haken and B. Blü;mich, “Anisotropy in Tendon Investigated in Vivo by a Portable NMR Scanner, the NMR-MOUSE,” Journal of Magnetic Resonance, vol. 144, no. 2, pp. 195–199, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Perlo, F. Casanova, and B. Blümich, “Profiles with microscopic resolution by single-sided NMR,” Journal of Magnetic Resonance, vol. 176, no. 1, pp. 64–70, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Danieli and B. Blümich, “Single-sided magnetic resonance profiling in biological and materials science,” Journal of Magnetic Resonance, vol. 229, pp. 142–154, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. P. J. McDonald, A. Akhmerov, L. J. Backhouse, and S. Pitts, “Magnetic resonance profiling of human skin in vivo using GARField magnets,” Journal of Pharmaceutical Sciences, vol. 94, no. 8, pp. 1850–1860, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Ciampi, M. Van Ginkel, P. J. McDonald et al., “Dynamic in vivo mapping of model moisturiser ingress into human skin by GARfield MRI,” NMR in Biomedicine, vol. 24, no. 2, pp. 135–144, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Bergman, Y. Sarda, N. Ritz et al., “In vivo assessment of aged human skin with a unilateral NMR scanner,” NMR in Biomedicine, vol. 28, no. 6, pp. 656–666, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Sarda, E. Bergman, I. Hillel, I. Binderman, and U. Nevo, “Detection of bone marrow changes related to estrogen withdrawal in rats with a tabletop stray-field NMR scanner,” Magnetic Resonance in Medicine, 2016. View at Publisher · View at Google Scholar
  27. A. Liberman, E. Bergman, Y. Sarda, and U. Nevo, “Faster imaging with a portable unilateral NMR device,” Journal of Magnetic Resonance, vol. 231, pp. 72–78, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Yaffe, H. Bahar, and I. Binderman, “Topical application of drugs influencing cytoskeleton and cell contractility affects alveolar bone loss in rats,” Journal of Periodontology, vol. 77, no. 5, pp. 826–831, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. B. Clarke, “Normal bone anatomy and physiology,” Clinical Journal of the American Society of Nephrology, vol. 3, no. 3, pp. 131–139, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. E. Bergman, A. Yeredor, and U. Nevo, “An estimation method for improved extraction of the decay curve signal from CPMG-like measurements with a unilateral scanner,” Journal of Magnetic Resonance, vol. 245, pp. 87–93, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. D. G. Rata, F. Casanova, J. Perlo, D. E. Demco, and B. Blümich, “Self-diffusion measurements by a mobile single-sided NMR sensor with improved magnetic field gradient,” Journal of Magnetic Resonance, vol. 180, no. 2, pp. 229–235, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. A. B. Hodsman, D. C. Bauer, D. W. Dempster et al., “Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use,” Endocrine Reviews, vol. 26, no. 5, pp. 688–703, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. H.-J. Choi, J.-A. Im, and S.-H. Kim, “Changes in bone markers after once-weekly low-dose alendronate in postmenopausal women with moderate bone loss,” Maturitas, vol. 60, no. 2, pp. 170–176, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. I. H. Kalfas, “Principles of bone healing,” Neurosurgical Focus, vol. 10, no. 4, pp. 1–4, 2001. View at Google Scholar · View at Scopus
  35. P. Aspenberg, H. K. Genant, T. Johansson et al., “Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures,” Journal of Bone and Mineral Research, vol. 25, no. 2, pp. 404–414, 2010. View at Publisher · View at Google Scholar · View at Scopus