Prevention of Osteoporosis in the Ovariectomized Rat by Oral Administration of a Nutraceutical Combination That Stimulates Nitric Oxide Production
Effect of 100 days treatment with E2 or COMB-4 on Total Body Mass, Fat Mass, and Lean Mass following OVX. Whole body dual energy X-ray absorptiometry (DXA) scan performed 100 days following surgery and subsequent treatment with either vehicle (SHAM and OVX), E2 (OVX + E2) or COMB 4 (OVX + COMB-4). Panel (a): total body mass (g ±SEM); p < 0.01 with respect to SHAM and E2. Panel (b): total fat mass (g ± SEM); p < 0.01; with respect to SHAM, E2, and COMB-4. Panel (c): total lean mass (g± SEM) p<0.01 with respect to SHAM, OVX, and E2. n = 8 per group.