Prevention of Osteoporosis in the Ovariectomized Rat by Oral Administration of a Nutraceutical Combination That Stimulates Nitric Oxide Production
Effect of 100 days treatment with E2 or COMB-4 on Bone Mineral Density following OVX. Panel (a): bone mineral density (BMD; g/cm2 + SEM) determined by DXA scan in SHAM, OVX, E2(OVX+E2), and COMB-4 (OVX+COMB-4). p < 0.001; p < 0.01 with respect to OVX; p < 0.05 respect to SHAM. Panel (b): BMD normalized by fat content in SHAM. OVX, E2 (OVX+E2), and COMB-4 (OVX+COMB-4). p < 0.01 with respect to OVX. n = 8 per group.