Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia
Figure 2
(a, b): A 40-year-old patient delivered a 736 g baby at 27 gestational weeks. Serum creatinine level was 2.06 mg/dl at 5 months after delivery. (a) A glomerulus shows segmental sclerosis and adhesion to Bowman’s capsule (arrowheads). Glomerular capillary wall is thickened with double contour (arrows). (PAS, ×400). (b) A collapsing glomerulus revealing focal segmental sclerosis (arrow) with fibrinous exudate (PAS-methenamine silver, ×400). (c) A 41-year-old patient delivered a 2372 g baby at 37 weeks. Proteinuria prolonged for 9 months after delivery. Upon electron microscopy, subendothelial edema is observed (stars) (×3,000). (d) Diffusion abnormalities in a 32-year-old preeclamptic woman with RPLS. She complained of a headache from the beginning of labor at 37 weeks and lost her consciousness. Blood pressure was 181 mmHg and proteinuria was 8,900 mg/day. MRI illustrates the lesion of posterior lobes at the onset of convulsion (left, arrows). She recovered consciousness in a week, and the lesion diminished completely in 8 months after delivery (right).
