Extracellular Matrix Remodeling of the Umbilical Cord in Pre-eclampsia as a Risk Factor for Fetal Hypertension

Table 1

Matrix metalloproteinases of umbilical cord tissues in pre-eclampsia (𝑛=10, *𝑃<.05, **𝑃<.01, ***𝑃<.001).

Matrix metalloproteinase	Umbilical cord artery		Umbilical cord vein		Wharton’s jelly
	control	Pre-eclamptic	control	pre-eclamptic	control	pre-eclamptic
collagenase
MMP-1 [mg/kg protein]	5.76	3.19***	3.72	4.47*	—	—
stromelysin
MMP-3 [mg/kg protein]	1.08	1.06	0.602	0.778**	—	—
gelatinase
MMP-2 [mg/kg protein]	75.4	48.0***	54.8	37.6***	—	—
MMP-9 [mg/kg protein]	0.444	0.639***	0.419	0.708***	—	—
matrilysin
MMP-7 [mg/kg protein]	0.258	0.365***	0.439	0.512*	1.663	1.682
MMP-26 [% of control]	100	92.4	100	72.7**	100	128.7**
Membrane-Type MMP
MT-MMP-1 [% of control]	100	174***	100	157***	100	53***
MT-MMP-2 [% of control]	100	309***	100	217***	100	183***
MT-MMP-3 [% of control]	100	52***	100	60***	100	299***
MT-MMP-5 [% of control]	100	107	100	240***	100	94