In Utero Programming of Later Adiposity: The Role of Fetal Growth Restriction

Figure 2

Schematic overview depicting key postulated molecular changes in adipose tissue and in hormonal status in the fetus and that may be involved in the development of later obesity following intrauterine growth restriction. For full explanation and definitions, see (Section 5). TGF-α1 (transforming growth factor alpha-1), CTGF (connective tissue growth factor), CYR61 (cysteine-rich, angiogenic inducer, 61), dermatopontin, and chymase-1.