Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved?

Figure 1

Atypical antipsychotics may impact fetal growth, by altering placental function. Atypical antipsychotics (AA) such as Clozapine are known to effect liver and pancreas function. Such effects can result in altered systemic glucose levels. During pregnancy, this can result in gestational diabetes or contribute to increased nutrient transport across the placenta. In addition, AA can be directly transported across the maternal-fetal interface and potentially impact fetal metabolic balance. However, AAs in the maternal system could impact placental development or function and alter the release of endocrine factors which would impact on fetal growth and development. *Adapted from [72].