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Journal of Pregnancy
Volume 2012, Article ID 508657, 6 pages
Research Article

The Impact of HIV on Maternal Morbidity in the Pre-HAART Era in Uganda

1ICAP, Mailman School of Public Health, Columbia University, P.O. Box 3567, Kampala, Uganda
2Department of Primary Health Care, University of Oxford, Oxford, OX1 2-ET, UK
3St. Raphael of St. Francis Hospital, Nsambya, Kampala, Uganda
4Institute for Women's Health, University College London, London, WC1E AU, UK
5Department of Public Health, University of Oxford, Oxford, OX3 7LF, UK

Received 13 June 2011; Accepted 20 July 2011

Academic Editor: Oliver Ezechi

Copyright © 2012 Harriet Nuwagaba-Biribonwoha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To compare maternal morbidity in HIV-infected and uninfected pregnant women. Methods. Major maternal morbidity (severe febrile illness, illnesses requiring hospital admissions, surgical revisions, or illnesses resulting in death) was measured prospectively in a cohort of HIV-infected and uninfected women followed from 36 weeks of pregnancy to 6 weeks after delivery. Odds ratios of major morbidity and associated factors were examined using logistic regression. Results. Major morbidity was observed in 46/129 (36%) and 104/390 (27%) of the HIV-infected and HIV-uninfected women, respectively, who remained in followup. In the multivariable analysis, major morbidity was independently associated with HIV infection, adjusted odds ratio (AOR) 1.7 (1.1 to 2.7), nulliparity (AOR 2.0 (1.3 to 3.0)), and lack of, or minimal, formal education (AOR 2.1 (1.1 to 3.8)). Conclusions. HIV was associated with a 70% increase in the odds of major maternal morbidity in these Ugandan mothers.