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Journal of Pregnancy
Volume 2012, Article ID 514345, 8 pages
http://dx.doi.org/10.1155/2012/514345
Review Article

Oral Iron Prophylaxis in Pregnancy: Not Too Little and Not Too Much!

Department of Obstetrics, Næstved Hospital, DK-4700 Næstved, Denmark

Received 7 May 2012; Accepted 8 June 2012

Academic Editor: Alexander Krafft

Copyright © 2012 Nils Milman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Milman, “Anemia—still a major health problem in many parts of the world!,” Annals of Hematology, vol. 90, no. 4, pp. 369–377, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. World Health Organization, “Worldwide prevalence of anaemia 1993—2005,” WHO Global Database on Anaemia, Switzerland, 2008, http://whqlibdoc.who.int/publications/2008/9789241596657_eng.pdf.
  3. N. Milman, A. O. Agger, and O. J. Nielsen, “Iron supplementation during pregnancy. Effect on iron status markers, serum erythropoietin and human placental lactogen. A placebo controlled study in 207 Danish women,” Danish Medical Bulletin, vol. 38, no. 6, pp. 471–476, 1991. View at Google Scholar · View at Scopus
  4. N. Milman, T. Bergholt, L. Eriksen et al., “Iron prophylaxis during pregnancy - How much iron is needed? A randomized dose-response study of 20–80 mg ferrous iron daily in pregnant women,” Acta Obstetricia et Gynecologica Scandinavica, vol. 84, no. 3, pp. 238–247, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. A. B. Bruner, A. Joffe, A. K. Duggan, J. F. Casella, and J. Brandt, “Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls,” The Lancet, vol. 348, no. 9033, pp. 992–996, 1996. View at Publisher · View at Google Scholar · View at Scopus
  6. T. W. Rowland, M. B. Deisroth, G. M. Green, and J. F. Kelleher, “The effect of iron therapy on the exercise capacity of nonanemic iron-deficient adolescent runners,” American Journal of Diseases of Children, vol. 142, no. 2, pp. 165–169, 1988. View at Google Scholar · View at Scopus
  7. M. E. Cogswell, I. Parvanta, L. Ickes, R. Yip, and G. M. Brittenham, “Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial,” American Journal of Clinical Nutrition, vol. 78, no. 4, pp. 773–781, 2003. View at Google Scholar · View at Scopus
  8. N. Milman, “Postpartum anemia I: definition, prevalence, causes, and consequences,” Annals of Hematology, vol. 90, pp. 1247–1253, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. J. L. Beard, M. K. Hendricks, E. M. Perez et al., “Maternal iron deficiency anemia affects postpartum emotions and cognition,” Journal of Nutrition, vol. 135, no. 2, pp. 267–272, 2005. View at Google Scholar · View at Scopus
  10. E. J. Corwin, L. E. Murray-Kolb, and J. L. Beard, “Low hemoglobin level is a risk factor for postpartum depression,” Journal of Nutrition, vol. 133, no. 12, pp. 4139–4142, 2003. View at Google Scholar · View at Scopus
  11. N. Milman, “Iron and pregnancy—a delicate balance,” Annals of Hematology, vol. 85, no. 9, pp. 559–565, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. World Health Organization, "Iron deficiency Anaemia: Assessment, prevention and control", WHO/NHD/01.3, 2001.
  13. T. H. Bothwell, “Iron requirements in pregnancy and strategies to meet them,” American Journal of Clinical Nutrition, vol. 72, pp. 257S–264S, 2000. View at Google Scholar · View at Scopus
  14. N. Milman, K. E. Byg, and L. Ovesen, “Iron status in Danes 1994: II: prevalence of iron deficiency and iron overload in 1319 Danish women aged 40–70 years. Influence of blood donation, alcohol intake and iron supplementation,” Annals of Hematology, vol. 79, no. 11, pp. 612–621, 2000. View at Google Scholar · View at Scopus
  15. K. Trygg, K. Lund-Larsen, B. Sandstad, H. J. Hoffman, G. Jacobsen, and L. S. Bakketeig, “Do pregnant smokers eat differently from pregnant non-smokers?” Paediatric and Perinatal Epidemiology, vol. 9, no. 3, pp. 307–319, 1995. View at Google Scholar · View at Scopus
  16. N. A. Alwan, D. C. Greenwood, N. A. B. Simpson, H. J. McArdle, K. M. Godfrey, and J. E. Cade, “Dietary iron intake during early pregnancy and birth outcomes in a cohort of British women,” Human Reproduction, vol. 26, no. 4, pp. 911–919, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Hauner, C. Vollhardt, K. T. M. Schneider, A. Zimmermann, T. Schuster, and U. Amann-Gassner, “The impact of nutritional fatty acids during pregnancy and lactation on early human adipose tissue development: rationale and design of the INFAT study,” Annals of Nutrition and Metabolism, vol. 54, no. 2, pp. 97–103, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Mastroiacovo, T. Mazzone, A. Addis et al., “High vitamin A intake in early pregnancy and major malformations: a multicenter prospective controlled study,” Teratology, vol. 59, pp. 7–11, 1999. View at Google Scholar
  19. Nordic Council of Ministers, Nordic Nutrition Recommendations 2004, Copenhagen, Denmark, 2004.
  20. J. Beard, “Iron deficiency alters brain development and functioning,” Journal of Nutrition, vol. 133, pp. 1468S–1472S, 2003. View at Google Scholar · View at Scopus
  21. S. Grantham-McGregor and C. Ani, “A review of studies on the effect of iron deficiency on cognitive development in children,” Journal of Nutrition, vol. 131, supplement 2, pp. 649S–666S, 2001. View at Google Scholar · View at Scopus
  22. N. Milman, “Iron prophylaxis in pregnancy—general or individual and in which dose?” Annals of Hematology, vol. 85, no. 12, pp. 821–828, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. K. F. Michaelsen, N. Milman, and G. Samuelson, “A longitudinal study of iron status in healthy Danish infants: effects of early iron status, growth velocity and dietary factors,” Acta Paediatrica, International Journal of Paediatrics, vol. 84, no. 9, pp. 1035–1044, 1995. View at Google Scholar · View at Scopus
  24. E. K. Hutton and E. S. Hassan, “Late vs early clamping of the umbilical cord in full-term neonates: systematic review and meta-analysis of controlled trials,” Journal of the American Medical Association, vol. 297, no. 11, pp. 1241–1252, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. N. K. Møller and T. Weber, “Early vs delayed clamping of the umbilical cord in full term, preterm and very preterm infants,” Ugeskr Laeger, vol. 170, pp. 1919–1921, 2008. View at Google Scholar
  26. L. H. Allen, “Anemia and iron deficiency: effects on pregnancy outcome,” American Journal of Clinical Nutrition, vol. 71, pp. 1280S–1284S, 2000. View at Google Scholar · View at Scopus
  27. K. M. Rasmussen and R. J. Stoltzfus, “New evidence that iron supplementation during pregnancy improves birth weight: new scientific questions,” The American Journal of Clinical Nutrition, vol. 78, no. 4, pp. 673–674, 2003. View at Google Scholar · View at Scopus
  28. U. Ramakrishnan, “Nutrition and low birth weight: from research to practice,” American Journal of Clinical Nutrition, vol. 79, no. 1, pp. 17–21, 2004. View at Google Scholar · View at Scopus
  29. M. Nybo, L. Friis-Hansen, P. Felding, and N. Milman, “Higher prevalence of anemia among pregnant immigrant women compared to pregnant ethnic Danish women,” Annals of Hematology, vol. 86, no. 9, pp. 647–651, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Bencaiova, U. von Mandach, and R. Zimmermann, “Iron prophylaxis in pregnancy: intravenous route versus oral route,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 144, no. 2, pp. 135–139, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. J. K. Thomsen, J. C. Prien-Larsen, A. Devantier, and N. Fogh-Andersen, “Low dose iron supplementation does not cover the need for iron during pregnancy,” Acta Obstetricia et Gynecologica Scandinavica, vol. 72, no. 2, pp. 93–98, 1993. View at Google Scholar · View at Scopus
  32. M. Moretti, M. Phillips, A. Abouzeid, R. N. Cataneo, and J. Greenberg, “Increased breath markers of oxidative stress in normal pregnancy and in preeclampsia,” American Journal of Obstetrics and Gynecology, vol. 190, no. 5, pp. 1184–1190, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. J. M. Morris, N. K. Gopaul, M. J. R. Endresen et al., “Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia,” British Journal of Obstetrics and Gynaecology, vol. 105, no. 11, pp. 1195–1199, 1998. View at Google Scholar · View at Scopus
  34. J. E. Toblli, G. Cao, L. Olivieri, and M. Angerosa, “Effects of iron deficiency anemia and its treatment with iron polymaltose complex in pregnant rats, their fetuses and placentas: oxidative stress markers and pregnancy outcome,” Placenta, vol. 33, pp. 81–87, 2012. View at Publisher · View at Google Scholar
  35. F. E. Viteri, E. Casanueva, M. C. Tolentino, J. Díaz-Francés, and A. B. Erazo, “Antenatal iron supplements consumed daily produce oxidative stress in contrast to weekly supplementation in Mexican non-anemic women,” Reproductive Toxicology, vol. 34, no. 1, pp. 125–132, 2012. View at Publisher · View at Google Scholar
  36. K. Schümann, S. Kroll, M. E. Romero-Abal et al., “Impact of oral iron challenges on circulating non-transferrin-bound iron in healthy Guatemalan males,” Annals of Nutrition and Metabolism, vol. 60, pp. 98–107, 2012. View at Publisher · View at Google Scholar
  37. L. Hallberg, L. Rossander, and A. B. Skaanberg, “Phytates and the inhibitory effect of bran on iron absorption in man,” American Journal of Clinical Nutrition, vol. 45, no. 5, pp. 988–996, 1987. View at Google Scholar · View at Scopus
  38. L. Hallberg, M. Brune, and L. Rossander, “Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate,” American Journal of Clinical Nutrition, vol. 49, no. 1, pp. 140–144, 1989. View at Google Scholar · View at Scopus
  39. L. Sölvell, “Oral iron therapy. Side effects,” in Iron Deficiency. Pathogenesis, Clinical Aspects, Therapy, L. Hallberg, H.-G. Harwerth, and A. Vannotti, Eds., pp. 573–583, Academic, London, UK, 1970. View at Google Scholar
  40. D. S. Kerr and S. Davidson, “Gastrointestinal intolerance to oral iron preparations,” The Lancet, vol. 272, no. 7045, pp. 489–492, 1958. View at Google Scholar · View at Scopus
  41. N. Milman, K. E. Byg, T. Bergholt, and L. Eriksen, “Side effects of oral iron prophylaxis in pregnancy—myth or reality?” Acta Haematologica, vol. 115, no. 1-2, pp. 53–57, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Layrisse, M. N. García-Casal, L. Solano et al., “Iron bioavailability in humans from breakfasts enriched with iron bis-glycine chelate, phytates and polyphenols,” Journal of Nutrition, vol. 130, no. 9, pp. 2195–2199, 2000. View at Google Scholar · View at Scopus
  43. R. Ortiz, J. E. Toblli, J. D. Romero et al., “Efficacy and safety of oral iron(III) polymaltose complex versus ferrous sulfate in pregnant women with iron-deficiency anemia: a multicenter, randomized, controlled study,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 24, pp. 1–6, 2011. View at Google Scholar
  44. M. Olivares, F. Pizarro, M. Ruz, and D. López de Romaña, “Acute inhibition of iron bioavailability by zinc: studies in humans,” Biometals.
  45. F. E. Viteri, E. Casanueva, M. C. Tolentino, J. Díaz-Francés, and A. B. Erazo, “Antenatal iron supplements consumed daily produce oxidative stress in contrast to weekly supplementation in Mexican non-anemic women,” Reproductive Toxicology, vol. 34, no. 1, pp. 125–132, 2012. View at Publisher · View at Google Scholar
  46. P. Pedersen, G. V. Melsen, and N. Milman, “Frequencies of the haemochromatosis gene (HFE) variants C282Y, H63D and S65C in 6,020 ethnic Danish men,” Annals of Hematology, vol. 87, no. 9, pp. 735–740, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. A. Pietrangelo, “Non-HFE hepatic iron overload,” Seminars in Liver Disease, vol. 31, pp. 302–318, 2011. View at Publisher · View at Google Scholar
  48. R. Stoltzfus and M. Dreyfuss, “. Guidelines for the use of iron supplements to prevent and treat iron deficiency anaemia,” The International Nutritional Anaemia Consultative Group, (INACG/WHO/UNICEF), Washington, DC, USA, 1998.
  49. E. C. Ekström, S. M. Z. Hyder, A. M. R. Chowdhury et al., “Efficacy and trial effectiveness of weekly and daily iron supplementation among pregnant women in rural Bangladesh: disentangling the issues,” American Journal of Clinical Nutrition, vol. 76, no. 6, pp. 1392–1400, 2002. View at Google Scholar · View at Scopus
  50. N. L. Sloan, E. Jordan, and B. Winikoff, “Effects of iron supplementation on maternal hematologic status in pregnancy,” American Journal of Public Health, vol. 92, no. 2, pp. 288–293, 2002. View at Google Scholar · View at Scopus
  51. G. O. Walters, F. M. Miller, and M. Worwood, “Serum ferritin concentration and iron stores in normal subjects,” Journal of Clinical Pathology, vol. 26, no. 10, pp. 770–772, 1973. View at Google Scholar · View at Scopus
  52. H. Strevens, H. Fadl, C. Weatergren, B. Knutson, and P. Ny, “A basic medical program in pregnant women,” in Antenatal Care, Sexual and Reproductive Health, pp. 47–48, Stockholm, Sweden, 2008, Rapport nr 59. View at Google Scholar
  53. B. Svanberg, “Absorption of iron in pregnancy,” Acta Obstetricia et Gynecologica Scandinavica, Supplement, vol. 48, pp. 87–108, 1975. View at Google Scholar
  54. H. C. Heinrich, H. Bartels, B. Heinisch et al., “Intestinale59Fe-resorption und prälatenter eisenmangel während der gravidität des menschen,” Klinische Wochenschrift, vol. 46, no. 4, pp. 199–202, 1968. View at Publisher · View at Google Scholar · View at Scopus
  55. J. F. R. Barrett, P. G. Whittaker, J. G. Williams, and T. Lind, “Absorption of non-haem iron from food during normal pregnancy,” British Medical Journal, vol. 309, no. 6947, pp. 79–82, 1994. View at Google Scholar · View at Scopus
  56. N. Milman, “Postpartum anemia II: prevention and treatment,” Annals of Hematology, vol. 91, pp. 143–154, 2012. View at Publisher · View at Google Scholar
  57. K. Mahomed, “Iron supplementation in pregnancy,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD000117, 2000. View at Google Scholar · View at Scopus