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Journal of Pregnancy
Volume 2012, Article ID 841979, 4 pages
Research Article

Risk Factors Associated with False Positive HIV Test Results in a Low-Risk Urban Obstetric Population

1Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9032, USA
2Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9032, USA

Received 21 April 2011; Accepted 22 June 2011

Academic Editor: Karen Odberg-Petterson

Copyright © 2012 Tamara T. Chao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To examine risk factors for false positive HIV enzyme immunoassay (EIA) testing at delivery. Study Design. A review of pregnant women who delivered at Parkland Hospital between 2005 and 2008 was performed. Patients routinely received serum HIV EIA testing at delivery, with positive results confirmed through immunofluorescent testing. Demographics, HIV, hepatitis B surface antigen (HBsAg), and rapid plasma reagin (RPR) results were obtained. Statistical analyses included Pearson's chi-square and Student's t-test. Results. Of 47,794 patients, 47,391 (99%) tested negative, 145 (0.3%) falsely positive, 172 (0.4%) positive, and 86 (0.2%) equivocal or missing HIV results. The positive predictive value of EIA was 54.3%. Patients with false positive results were more likely nulliparous (43% versus 31%, 𝑃 < 0 . 0 0 1 ) and younger ( 2 3 . 9 ± 5 . 7 versus 2 6 . 2 ± 5 . 9 years, 𝑃 < 0 . 0 0 1 ). HIV positive patients were older than false positive patients and more likely positive for HBsAg and RPR. Conclusion. False positive HIV testing at delivery using EIA is associated with young maternal age and nulliparity in this population.