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Journal of Pregnancy
Volume 2012, Article ID 858097, 8 pages
Research Article

Migraine-Asthma Comorbidity and Risk of Hypertensive Disorders of Pregnancy

1Multidisciplinary International Research Training Program, University of Washington, Seattle, WA 98195, USA
2Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98104, USA
3Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA

Received 19 January 2012; Accepted 16 June 2012

Academic Editor: Antonio Farina

Copyright © 2012 Stefanie Czerwinski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. To evaluate the association of migraine and asthma and to estimate the risk of hypertensive disorders of pregnancy in relation to maternal comorbid migraine and asthma. Methods. Reproductive age women (N=3.731) were interviewed during early pregnancy. At the time of interview, we ascertained participants’ migraine and asthma status. From medical records, we collected information to allow the diagnosis of pregnancy-induced hypertension (PIH) and preeclampsia. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression procedures. Results. After adjusting for confounders, migraineurs had 1.38-fold increased odds of asthma as compared with nonmigraineurs (95% CI 1.09–1.38). The odds of hypertensive disorders of pregnancy were highest among women with comorbid migraine-asthma. The ORs for PIH preeclampsia and the two disorders combined were 2.53 (95% CI 1.39–4.61), 3.53 (95% CI 1.51–8.24), and 2.64 (95% CI 1.56–4.47), respectively, for women with comorbid migraine-asthma as compared with those who had neither disorder. Conclusion. These findings confirm prior reports and extend the literature by documenting particularly high odds of pregnancy-induced hypertension and preeclampsia among women with comorbid migraine-asthma. Increased knowledge about the prevalence and sequelae of comorbidities during pregnancy may lead to improved symptom management and perinatal outcomes.