Revisiting the Role of First Trimester Homocysteine as an Index of Maternal and Fetal Outcome

Table 2

Homocysteine levels with reference to outcome of past pregnancies.

	No prior first trimester loss; (𝑛 = 64)	One prior first trimester loss; (𝑛 = 27)	Two prior first trimester losses; (𝑛 = 9)		𝑃 value	Test used
Serum homocysteine (𝜇mol/L)	12.80 ± 6.58	15.25 ± 7.58	17.08 ± 5.80		0.1687	One way ANOVA
	No prior second trimester loss; (𝑛 = 88)	One prior second trimester loss; (𝑛 = 9)	Two prior second trimester losses; (𝑛 = 3)
Serum homocysteine (𝜇mol/L)	13.59 ± 7.02	16.72 ± 2.89	6.52 ± 0.50		0.0307 *	Kruskal-Wallis test
	No intrauterine fetal death in the third trimester; (𝑛 = 91)	One previous intrauterine fetal death in the third trimester; (𝑛 = 9)
Serum homocysteine (𝜇mol/L)	13.16 ± 5.75	23.79 ± 9.21			<0.0001 **	Unpaired 𝑡-test
	No prior pregnancy loss (any trimester); (𝑛 = 52)	One prior pregnancy loss; (𝑛 = 25)	Two prior pregnancy losses; (𝑛 = 19)	Three prior pregnancy losses; (𝑛 = 4)
Serum homocysteine (𝜇mol/L)	11.08 ± 4.18	13.46 ± 7.15	19.23 ± 6.65	17.80 ± 6.41	0.0002 **	Kruskal-Wallis test

^∗𝑃≤0.05 significant.
** 𝑃≤0.001 highly significant.