Revisiting the Role of First Trimester Homocysteine as an Index of Maternal and Fetal Outcome

Table 4

Homocysteine levels with reference to fetal outcome of present pregnancy.

	No fetal congenital malformation; (𝑛 = 88)	Fetal congenital malformation; (𝑛 = 2)	𝑃 value	Statistical test used
Serum homocysteine (𝜇mol/L)	14.56 ± 8.0	12.07 ± 1.75	0.6621	Mann-Whitney 𝑈 test
	No pregnancy loss; (𝑛 = 82)	Pregnancy loss; (𝑛 = 8)
Serum homocysteine (𝜇mol/L)	13.51 ± 7.47	24.65 ± 4.51	0.0002 **	Mann-Whitney 𝑈 test
	Clear amniotic fluid; (𝑛 = 67)	Meconium stained amniotic fluid; (𝑛 = 17)
Serum homocysteine (𝜇mol/L)	12.52 ± 6.94	18.43 ± 8.48	0.0037 *	Mann-Whitney 𝑈 test
	No oligohydramnios; (𝑛 = 66)	Oligohydramnios; (𝑛 = 18)
Serum homocysteine (𝜇mol/L)	12.58 ± 7.01	20.02 ± 7.92	<0.0001 **	Mann-Whitney 𝑈 test
	Birth weight; ≥2500 gm; (𝑛 = 73)	Birth weight; <2500 gm; (𝑛 = 11)
Serum homocysteine (𝜇mol/L)	12.35 ± 5.64	23.22 ± 12.32	0.0224 *	Unpaired 𝑡-test—Welch correction

^∗𝑃≤0.05 significant.
** 𝑃≤0.001 highly significant.