Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age

Table 3

Correlation between ultrasound markers and Down syndrome.

Marker	Down syndrome		Statistical analysis
	Present	Absent
Nuchal fold thickness ≥ 6 mm	12/31	35/858	𝑃<0.001
Intracardiac hyperechogenic focus	4/31	35/858	𝑃=0.05
Short femur length	1/31	2/858	𝑃=0.10
Structural malformation	6/31	26/858
Duodenal Atresia	1	5	𝑃<0.001
Esophageal Atresia	1	4
Cystic Hygroma	3	0
Meningomyelocele	0	6
Spina Bifida	0	4
Congenital heart disease	1	2
Hydrocephalus	0	5