Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age

Table 5

Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the ultrasound markers for detecting Down syndrome.

Marker	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Nuchal fold thickness ≥ 6 mm	38.7	95.9	25.5	97.7
Short femur length	32.3	99.8	33.3	96.6
Intracardiac hyperechogenic focus	12.9	95.9	10.3	96.8
Structural fetal malformation	19.3	97.0	18.8	97.1