Genetic Aspects of Preeclampsia and the HELLP Syndrome

Table 2

OR impact on preeclampsia and HELLP.

Gene variant	Preeclampsia compared to	HELLP compared to	Number	OR (95% CI)	References
Factor V Leiden mutation		Healthy pregnancy	71	4.45 (1.31–15.31)	[69]
Factor Leiden mutation; 169G-A SNP	Healthy pregnancy		1,798	1.81 (1.14–2.87)	[70]
Factor V Leiden mutation		Healthy pregnancy	32	2.29 (0.56–9.32)	[45]
Factor II prothrombin mutation		Healthy pregnancy	32	6.03 (0.65–47.54)	[45]
Three mutations		Healthy pregnancy	7,522	1.84 (1.14–2.87)	[71]
MTHFR 677C-T SNP	Healthy pregnancy		2,250	1.01 (0.79–1.29)	[1]
VEGF C −460T SNP		Healthy pregnancy	71	Adjusted; OR 3.95 (1.51–6.08)	[72]
VEGFG 405C SNP		Healthy pregnancy	71	Adjusted; OR 3.67 (1.05–1.75)	[72]
BclI polymorphism of GR gene		Healthy pregnancy	17	Adjusted; OR 2.89 (1.45–5.74)	[49]
BclI polymorphism of GR gene	Severe preeclampsia		150	2.56 (1.45–5.74)	[49]
Polymorphism of EPHX gene	Healthy pregnancy		87	2.0 (1.2–3.7)	[49]
Fas TNFRSF6 gene		Healthy pregnancy	84	2.7 (1.2–5.9)	[51]
TLR-4 gene		Healthy pregnancy	177	4.1 (1.7–9.8)	[52]
Combined TLR-4 and NOD2 variant and high levels of IL-6	Healthy pregnancy		177	6.9 (2.1–23.2)	[52]
I/II genotype of LEPR gene	Healthy pregnancy		40	3.8 (0.8–18.0)	[73]
LEPR 223G allele	LEPR 23A/A; genotype		24	1.92 (1.07–3.41)	[54]