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Journal of Pregnancy
Volume 2015, Article ID 132718, 6 pages
http://dx.doi.org/10.1155/2015/132718
Research Article

Impaired Fertility Associated with Subclinical Hypothyroidism and Thyroid Autoimmunity: The Danish General Suburban Population Study

1Department of Obstetrics & Gynaecology, Naestved Hospital, Ringstedgade 61, 4700 Naestved, Denmark
2The Mitochondrial Research Unit, Naestved Hospital, Ringstedgade 61, 4700 Naestved, Denmark
3Department of Clinical Biochemistry, Naestved Hospital, Ringstedgade 61, 4700 Naestved, Denmark
4Department of Clinical Pathology, Naestved Hospital, Ringstedgade 61, 4700 Naestved, Denmark
5Department of Otorhinolaryngology-Head and Neck Surgery, Koege Hospital, Lykkebaekvej 1, 4600 Koege, Denmark
6Department of Research, Nykoebing F. Hospital, 4800 Nykobing Falster, Denmark
7Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
8Department of Internal Medicine, Naestved Hospital, Ringstedgade 61, 4700 Naestved, Denmark
9Institute of Regional Health Services, University of Southern Denmark, Denmark

Received 26 April 2015; Revised 3 August 2015; Accepted 5 August 2015

Academic Editor: Jeffrey Keelan

Copyright © 2015 Anne-Dorthe Feldthusen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. The aim of this study was to estimate the significance of TSH, thyroid peroxidase antibody (TPOAb), and mild (subclinical) hypothyroidism in women from The Danish General Suburban Population Study (GESUS) on the number of children born, the number of pregnancies, and the number of spontaneous abortions. Methods. Retrospective cross sectional study of 11254 women participating in GESUS. Data included biochemical measurements and a self-administrated questionnaire. Results. 6.7% had mild (subclinical) hypothyroidism and 9.4% prevalent hypothyroidism. In women with mild hypothyroidism TPOAb was significantly elevated and age at first child was older compared to controls. TSH and TPOAb were negatively linearly associated with the number of children born and the number of pregnancies in the full cohort in age-adjusted and multiadjusted models. TSH or TPOAb was not associated with spontaneous abortions. Mild (subclinical) hypothyroidism was associated with a risk of not having children and a risk of not getting pregnant in age-adjusted and multiadjusted models. Prevalent hypothyroidism was not associated with the number of children born, the number of pregnancies, or spontaneous abortions. Conclusion. Impaired fertility is associated with TSH, TPOAb, and mild (subclinical) hypothyroidism in a Danish population of women.