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Journal of Pregnancy
Volume 2015 (2015), Article ID 320386, 10 pages
http://dx.doi.org/10.1155/2015/320386
Review Article

AngiomiRs: Potential Biomarkers of Pregnancy’s Vascular Pathologies

1Basic Sciences School, Health Faculty, Universidad del Valle, Sede San Fernando, Calle 4B No. 36-00, 760043 Cali, Valle del Cauca, Colombia
2Department of Biological Sciences, Natural Sciences Faculty, Universidad ICESI, Calle 18 No. 122-135, 760031 Cali, Valle del Cauca, Colombia

Received 18 August 2015; Accepted 27 September 2015

Academic Editor: Jeffrey Keelan

Copyright © 2015 Laura María Rodríguez Santa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In recent years, microRNAs (miRNAs) have been the focus of research for their role in posttranscriptional regulation and as potential biomarkers of risk for disease development. Their identification in specific physiological processes, like angiogenesis, a key pathway in placental vascular development in pregnancy, suggests an important role of miRNAs that regulate angiogenesis (angiomiRs). Many complications of pregnancy have in common placental vascular alterations, involving an imbalance in the angiogenesis process in the development of conditions such as preeclampsia, intrauterine growth restriction, and gestational diabetes, complications with the highest rates of morbimortality in pregnancy. Many studies have identified angiomiRs with differential expression profiles in each of these diseases; however, this evidence requires further studies focused on evaluating their potential as biomarkers of risk for the angiomiRs detected, to establish correlations between placental tissue and serum/plasma expression profiles. Therefore, the objective of this review is to highlight the best angiomiRs detected in placental tissue and serum/plasma in each of these three pathologies to show the current data available for potential biomarkers and to propose future research strategies on this topic.