Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity

Figure 3

Cell recruitment, invasion, and spatial distribution and communication of foetal and maternal cells in the pre- and postimplantation tissue reorganization during placental formation. Decidual transformation of maternal endometrium is induced by ovary hormones and secretory factors released by the embryo. Recruitment of immune cells is performed by chemokines secreted from the differentiating endometrial and trophoblast cells. Immune cell maintenance/proliferation and differentiation are regulated by the cytokines and factors from endometrial and trophoblast cells creating a prompting microenvironment.