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Journal of Pregnancy
Volume 2017 (2017), Article ID 3179670, 5 pages
Research Article

Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients

1Department of Biochemistry, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, India
2Department of Obstetrics and Gynaecology, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, India

Correspondence should be addressed to Pradeep Kumar Patra

Received 26 August 2016; Revised 29 November 2016; Accepted 13 December 2016; Published 4 January 2017

Academic Editor: Albert Fortuny

Copyright © 2017 Vibha Tandon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The objective of the study was to assess the serum vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) and find association between serum VEGF levels and PIH. Methods. Thirty-five PIH subjects, 35 normal pregnant females, and 20 normal healthy females were included in the study. Detailed history, clinical examination, and relevant biochemical parameters were assessed; serum VEGF levels were estimated using Double-antibody enzyme-linked immunosorbent assay. Results. The study groups were found to be age matched (). VEGF level in the pregnancy-induced hypertensive group (median = 109.19 ()) was significantly higher than the normal pregnant (median = 20.82 (1.7–619)) and control (median = 4.92 (1.13–13.07)) group and the difference between these three groups was significant (). The 3 groups are found to be significantly different in terms of RBS (), urea (), creatinine (), AST (), ALT (), total protein (), albumin (), calcium (), and sodium (), while no statistically significant difference was found between total bilirubin (), direct bilirubin (), uric acid (), and potassium (). Conclusion. Significantly higher levels of serum VEGF were noted in PIH subjects compared to normal pregnant and control subjects.