Early Pregnancy Serum Metabolite Profiles Associated with Hypertensive Disorders of Pregnancy in African American Women: A Pilot Study

Figure 3

Preeclampsia vs. gestational hypertension. (a) Type 1 Manhattan plot, -log₁₀ vs. mass-to-charge ratio. features were found significant at value 0.05. No metabolites were significant by false discovery rate (FDR) value 0.20. Red dots represent those features downregulated in gestational hypertension (gHTN), and the blue dots represent features that were downregulated in PE. (b) Type 2 Manhattan plot, -log₁₀ vs. retention time. (c) 2-way hierarchical cluster analysis. gHTN is represented in red and preeclampsia in green across the -axis; significant features are clustered on the -axis; there is clear separation between the two groups of women. (d) Principal component analysis.

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