Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome

Table 1

Genes and SNPs associated with preeclampsia.

Gene	SNP	Study size (case/control)	Sample origin	Association	Reference
IL1RL1	rs1420103	214/208	Mother	GG increases mild preeclampsia risk; TT reduces late-onset severe preeclampsia	[47]
	rs13017455			CT reduces preeclampsia risk
ACVR2A	rs1424954	613/693	Mother	These SNPs were associated with the more severe early onset preeclampsia	[104]
MTHFR	rs1801131	150/150	Mother	CC genotype increases risk	[105]
		192/196	Mother	The synergic (rs1801131+rs1801133) effect of MTHFR variants could increase PE and EOPE risk	[106]
	rs1801133
		198/101	Mother	Increased risk	[107]
		125/274	Mother	Protective effect	[108]
IL-1B	rs1143630	169/287	Mother	“T” allele increase risk	[109]
C6	rs7444800	203/233	Mother	Genetic variations in this gene increase risk, and the risk varied by preeclampsia subtypes	[110]
	rs4957381
MASP1	rs1108450
	rs3774282
	rs698106
VEGF and VEGFR1	VEGFR1 rs722503	165/191	Mother	Increase risk after the age of 40 years	[111]
	VEGFA rs3025039			C allele increase risk; T allele protective allele
HLA-G	rs17179101 and rs9380142	47/68	Mother	This SNP combination increases risk	[112]
	HLA-G 0106G	83/240	Mother	Increased risk	[113]
IL-10	rs1800896	151/189	Mother	Increased risk	[44]
		134/164	Mother	Increased risk	[45]
		101/91	Mother	AA allele increases risk	[46]
ICOS	rs4675378	130/260	Mother	T allele and TT genotype protective allele	[114]
GSTP1	rs1695	113 trios/317 (149 men, 168 women)	Mother/father/child	This polymorphism in paternal and fetal GSTP1 gene increases risk	[41]
		125/274	Mother	G allele protective effect	[108]
TGF-B1	rs1800470	175/253	Mother	TT genotype protective allele	[115]
IL-6	rs1800795	116/107	Mother	C allele protective allele	[116]
NLRP1	rs12150220	286/309	Mother	Risk effect	[117]
eNOS	rs1799983	322/522	Mother	Risk effect	[118]
	rs2297518	353/212	Mother	A allele increases risk	[119]
IL-1A	rs3783550	79/210	Mother	A allele increases risk	[120]
ACE	rs1799752	66/37	Mother	DD genotype and D allele increase risk	[121]
EDN1	rs5370	61/49	Mother/father	rs5370 SNP protective effect	[122]
ERAP2	rs2549782	528/575	Mother and neonates	Risk effect	[123]
GSTM1	rs4025935	Mother	112/233	GSTT1 deletion and combined GSTM1/GSTT1 deletion increase risk	[124]
GSTT1	rs71748309	Mother	112/233