Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome

Table 2

Genes associated with preeclampsia by GWAS.

Gene	SNP	Sample origin	Study size (case/control)	Effect	Reference
MTHFR	rs17367504	Mother	1006/816	Protective effect	[52]
ATP2B1	rs17249754a	Mother	1006/816	Protective effect
PAX5	rs16933812a	Mother	1006/816	Protective effect
PLCD3	rs12946454a	Mother	1006/816	Protective effect
INHIBIN	rs7579169	Mother	538/540	Risk effect	[51]
KIAA1239	rs1426409	Mother	177/116	Risk effect	[125]
ESRRG	rs17686866	Mother	177/116	Risk effect
LMCD1	rs9831647	Mother	177/116	Risk effect
IFLTD1	rs10743565	Mother	177/116	Risk effect
PSG11	rs10412348	Mother	177/116	Risk effect
FGF14	rs11617740	Mother	137/2986	Multicenter study: none detected SNP reached Bonferroni-corrected significance due to the small number of cases	[126]
C21orf121	rs2839440	Mother	137/2986
MGC45800	rs12641856	Mother	137/2986
MCM8	rs4815879	Mother	137/2986
MUC21	rs28360974	Mother	137/2986
BAMBI	rs1248993	Mother	137/2986
NPVF	rs975369	Mother	137/2986
ADRA1D	rs1556832	Mother	137/2986
SCN2B	rs11600901	Mother	137/2986
MYCBP2	rs7322722	Mother	137/2986
INVS	rs10989019	Mother	137/2986
FLT1	rs4769613	Child	4380/310,238	C allele increases risk effect	[53]
PLEKHG1	rs9478812	Mother	877/2004	Risk effect	[127]