Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome

Table 3

Genes associated with PE by microarrays studies.

Gene	Study size	Tissue	Fold change	Reference
PRG2	4/4	Syncytiotrophoblast severe preeclampsia (placenta)	6.4	[128]
FSTL3	4/4		3.7
FABP4	4/4		3.5
RDH13	4/4		3.1
PLAC1	4/4		-3.4
SERPINI1	4/4		-4.4
GSTA3	4/4		-4.8
CXCL8	3/4	Cytotrophoblast severe preeclampsia (placenta)	3.5	[129]
GH2	3/4		-14.2
sFLT1	21/21	Placenta (full thickness)	2.6	[58]
ENG	23/37		1.852.919.237
INHIBIN	21/21		3.0	[58, 130, 131]
SIAE	23/37		1.354.912.795	[58]
PAPPA2	21/21		2.9
BRSK2	21/21		8.6
FLJ90650	21/21		10.0
LEP	21/21		40.0
LHB	21/21		4.1
PDGFD	21/21		-2.3
COX17	21/21		-4.3
HS3ST2	60/65	Maternal placenta (decidua basalis)	-1.39	[130]
TNFRSF14	60/65		-1.35
SLC2A6	60/65		-1.32
DPP7	60/65		-1.22
CD72	60/65		-1.21
PER3	60/65		-1.20
DBP	60/65		-1.20
PDK4	60/65		1.72
HS3ST2	60/65		-1.39
COL17A1	6/6	Placental biopsies	6.6	[56]
KRT2	6/6		6.4
NCAM1	6/6		3.8
PKP2	6/6		3.2
BMP2	6/6		-3.9
CDH3	6/6		-4.3
LEP OB/OBS	6/6		43.6
MEF2A	6/6		3.9
MUC1	6/6		3.6