Journal of Pregnancy

Basic Experimental and Clinical Advances in the Mechanisms Underlying Abnormal Pregnancy Outcomes


Publishing date
03 Aug 2012
Status
Published
Submission deadline
03 Feb 2012

1Department of Obstetrics and Gynaecology, Children's Health Research Institute, London, ON, Canada N6C 2V5; The Lawson Research Institute, The University of Western Ontario, London, ON, Canada N6A 3K7

2Early Origins of Adult Health Research Group, University of South Australia, SA 5001, Australia

3Center for Pregnancy and Newborn Research, UT Health Science Center at San Antonio, TX 78229-3901, USA


Basic Experimental and Clinical Advances in the Mechanisms Underlying Abnormal Pregnancy Outcomes

Description

In utero growth and development are a complex process leading to additional developmental milestones during postnatal life. Adverse stimuli or insults during this critical period of intrauterine growth and development are now understood to alter the genetically dictated growth trajectory of the fetus and reprogram the newborn's long-term development and physiological path. Basic experimental and clinical human studies demonstrate that fetal growth restriction may result from in utero insults such as uteroplacental sufficiency and/or hypoxia, and may be associated with the development of metabolic syndrome in postnatal life. The “thrifty phenotype hypothesis” has been proposed to explain how in utero responsive adaptations set in motion the series of developmental and physiological adaptations to maximize in utero survival chances. While low birth weight is recognized as a risk factor for metabolic syndrome, it is now apparent that a U-shaped relationship exists between excessive birth weight and increasing risks of metabolic syndrome as well, further highlighting the critically important role, fetal growth, and development play in setting the stage for postnatal life disease risk and health.

We invite investigators to contribute both review and original research articles concerning fetal development in the extremes of birth weights, especially those articles dealing with potential reprogramming of postnatal outcomes associated with an increase of metabolic syndrome. In this edition we wish to specifically collect important contributions related to, but are not limited to:

  • Detection and predictive value of ultrasound and other imaging modalities in abnormal pregnancies
  • Studies concerning placental function in both low birth weight (e.g., IUGR, preeclampsia, etc.) as well as high birth weight (e.g., LGA and macrocosmic infants)
  • Reports detailing detection of markers of altered fetal development and reprogramming
  • Molecular mechanisms behind altered fetal organ development and function in utero
  • The plasticity of organ systems following an in utero insult and their interrelationships with postnatal whole-body physiology
  • Long-term follow-up experimental and human studies following an abnormal pregnancy

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jp/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 327638
  • - Editorial

Basic Experimental and Clinical Advances in the Mechanisms Underlying Abnormal Pregnancy Outcomes

Timothy R. H. Regnault | Mark J. Nijland | ... | Janna L. Morrison
  • Special Issue
  • - Volume 2012
  • - Article ID 179827
  • - Review Article

Regulation of Nutrient Transport across the Placenta

Susanne Lager | Theresa L. Powell
  • Special Issue
  • - Volume 2012
  • - Article ID 134758
  • - Review Article

In Utero Programming of Later Adiposity: The Role of Fetal Growth Restriction

Ousseynou Sarr | Kaiping Yang | Timothy R. H. Regnault
  • Special Issue
  • - Volume 2012
  • - Article ID 839656
  • - Review Article

Antenatal Steroids and the IUGR Fetus: Are Exposure and Physiological Effects on the Lung and Cardiovascular System the Same as in Normally Grown Fetuses?

Janna L. Morrison | Kimberley J. Botting | ... | Sandra Orgeig
  • Special Issue
  • - Volume 2012
  • - Article ID 638476
  • - Review Article

The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult Disease

Stephanie E. Hallows | Timothy R. H. Regnault | Dean H. Betts
  • Special Issue
  • - Volume 2012
  • - Article ID 482690
  • - Review Article

The Fetal Origins of the Metabolic Syndrome: Can We Intervene?

Noelle Ma | Daniel B. Hardy
  • Special Issue
  • - Volume 2012
  • - Article ID 751694
  • - Review Article

Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad

Laura Bennet | Joanne O. Davidson | ... | Alistair Jan Gunn
  • Special Issue
  • - Volume 2012
  • - Article ID 792934
  • - Review Article

Fetal Programming of the Neuroendocrine-Immune System and Metabolic Disease

R. E. Fisher | M. Steele | N. A. Karrow
  • Special Issue
  • - Volume 2012
  • - Article ID 631038
  • - Review Article

Developmental Programming in Response to Intrauterine Growth Restriction Impairs Myoblast Function and Skeletal Muscle Metabolism

D. T. Yates | A. R. Macko | ... | S. W. Limesand
  • Special Issue
  • - Volume 2012
  • - Article ID 582748
  • - Review Article

Impact of Oxidative Stress in Fetal Programming

Loren P. Thompson | Yazan Al-Hasan
Journal of Pregnancy
 Journal metrics
Acceptance rate32%
Submission to final decision94 days
Acceptance to publication68 days
CiteScore1.580
Impact Factor-
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