Research Article

Schizophrenia: A Pathogenetic Autoimmune Disease Caused by Viruses and Pathogens and Dependent on Genes

Table 4

Viruses reported to bind to DISC1 interactome partners.

DISC1 partner gene symbolProtein nameViral binder

ACTG1Actin, cytoplasmic 2HIV-1 [97] HSV1 [98]
ACTN2Actinin, alpha 2Hepatitis C [99]
AKAP9A-kinase anchor protein 9Epstein-Barr [97]
ATF4Cyclic AMP-dependent transcription factor ATF-4HSV1 [98]
ATF5Cyclic AMP-dependent transcription factor ATF-5HTLV1 [100]
BICD1Protein bicaudal D homolog 1Cytomegalovirus [101]
C14orf135Uncharacterized protein C14orf135 precursorHepatitis C [102]
DCTN1Dynactin-1HSV1 [98]
DCTN2Dynactin subunit 2Dynactins are involved in the transport of the adenoviruses, HSV-1, the hantaan virus, HTLV-1 and the poliovirus [103108]
DNAJC7DnaJ homolog subfamily C member 7Part of a complex forming the coxsackie virus receptor [109]
DYNC1H1Dynein heavy chain, cytosolicAdenovirus (in a complex with dynactin and NDEL1) [110]
EEF2Elongation factor 2Epstein Barr [111]
EIF3S3Eukaryotic translation initiation factor 3 subunit 3Hepatitis C [112]
FEZ1Fasciculation and elongation protein zeta 1 (zygin I)JC Polyomavirus [113]
HERC2HECT domain and RCC1-like domain-containing protein 2Papillomavirus 16 [114]
KIF3CKinesin-like protein KIF3CHIV-1 [115]
MATR3Matrin-3HSV1 [98]
NDEL1Nuclear distribution protein nudE-like 1Part of a complex involved in Adenovirus transport (with dynactin and cytoplasmic dynein) [110]
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alphaBinds to Poliovirus P3 protein and HIV-1 Tat [116, 117]
PCNTPericentrinInvolved in the microtubular transport of the adenovirus [118]
PGK1Phosphoglycerate kinase 1 Epstein-Barr [119]
SMARCE1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1HSV-1 [97]
STX18Syntaxin-18 Papillomavirus [119]
TNKSTankyrase-1 Epstein-Barr [120]
TUBBTubulin beta chain Epstein-Barr [119]
YWHAE14-3-3 protein epsilonHepatitis C [97] :  L : Epstein-Barr [119]
YWHAQ14-3-3 protein thetaHIV [97] HSV1 [98]
YWHAZ14-3-3 protein zeta/deltaHSV1 [98] : Epstein-Barr [119]