Research Article

Schizophrenia: A Pathogenetic Autoimmune Disease Caused by Viruses and Pathogens and Dependent on Genes

Table 5

The number of schizophrenia gene products in KEGG pathways related to immunity, and viral or pathogen life cycles.

Pathogen pathwaysViral pathwaysImmune

Toxoplasmosis16Focal adhesion20Cytokine-cytokine receptor interaction26
Chagas disease15Cell adhesion molecules (CAMs)19Jak-STAT signaling pathway16
Amoebiasis13Regulation of actin cytoskeleton17Systemic lupus erythematosus13
Leishmaniasis12Protein processing in endoplasmic reticulum13T cell receptor signaling pathway13
Viral myocarditis8Endocytosis12Phagosome12
Staphylococcus aureus infection7Phagosome12Allograft rejection11
Epithelial cell signaling in Helicobacter pylori infection6Gap junction11Hematopoietic cell lineage11
Malaria6Tight junction11Antigen processing and presentation10
Tryptophan metabolism6Adherens junction6Fc epsilon RI signaling pathway10
NOD-like receptor signaling pathway4ECM-receptor interaction6Apoptosis10
Vibrio cholerae infection4Oocyte meiosis5Graft-versus-host disease9
Bacterial invasion of epithelial cells3SNARE interactions in vesicular transport4Autoimmune thyroid disease8
E.coli infection3Chemokine signaling pathway8
RIG-I-like receptor signaling pathway3Basal transcription factors3Leukocyte transendothelial migration8
Cytosolic DNA-sensing pathway2Spliceosome2Natural killer cell mediated cytotoxicity8
Shigellosis2Aminoacyl-tRNA biosynthesis1Adipocytokine signaling pathway7
Base excision repair1Asthma7
RNA degradation1Intestinal IgA production5
Toll-like receptor signaling pathway5
Complement and coagulation cascades4
B cell receptor signaling pathway3
TGF-beta signaling pathway3
Lysosome2
Regulation of autophagy2
Fc gamma R-mediated phagocytosis1
Primary immunodeficiency1