429069.fig.004a
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429069.fig.004b
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Figure 4: Physiopathological scheme of Yersinia infection (adapted from [13]). The Yops are delivered into the host cells via a type III secretion system. YopH, a tyrosine phosphatase, dephosphorylates Cas and FAK (protein tyrosine kinase) in epithelial cells, and Cas, Fyb, and SKAP-HOM in macrophages that are involved in the assembly of cytoskeletal complexes required for phagocytosis [78]; YopT modifies the Rho family GTPases by inducing redistribution of the RhoA GTPase [79]; YopE inactivates the Rho family of GTPases involved in phagocytosis [80]; YpkA binds to Rac and Rho (function unknown). These four Yops alter or disrupt the actin cytoskeleton and thereby block phagocytosis. YopJ impairs activation of MAPKKs and NF-B, which induces apoptosis and inhibits cytokine production. YopM is translocated into the nucleus (function unknown).