Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses
Figure 6
3D representation with predicted disorder annotation of the parts of the nucleocapsid proteins of IBV and SARS-CoV [7, 8]. (a) SARS-CoV (PDB ID: 2gib); (b) IBV (PDB ID: 2c86) Avian infectious bronchitis virus (IBV). The red color denotes residues predicted to be disordered by PONDR VLXT, while cyan and green represent regions that are predicted to be ordered with the two colors used to distinguish between separate subunits. The mean PID of the IBV N-protein is 56%, whereas the corresponding PID of SARS-CoV N-protein is only 50% (see Table 3). The N-protein of HCoV-299E is more similar to the IBV N-protein in this respect.
