Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity

Figure 5

TEM images under iron deprivation. (a) TEM images for M. smegmatis cells grown in the absence (control) of 2,2, BP (35 μg/mL) and drugs EMB, INH, and RIF with subinhibitory concentrations (62.5 ng/mL, 1 μg/mL, and 62.5 ng/mL) alone showing smooth cell envelope. (b) TEM images for M. smegmatis cells grown in the presence of drugs (EMB, INH, and RIF) with subinhibitory concentrations (62.5 ng/mL, 1 μg/mL, and 62.5 ng/mL) along with 2,2, BP (35 μg/mL) showing tampered and elongated morphology.

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