Novel Genetic Variants of Hepatitis B Virus in Fulminant Hepatitis

Table 2

The best combination of six candidate nucleotides of HBV associated with fulminant hepatitis was chosen from top 55 candidate nucleotides using brute force selection method implemented with SVM dot kernel algorithm.

Nucleotide	Gene/regulatory element	Fulminant, (% sensitivity)	Acute, (% specificity)	% accuracy	value
C2129	Core	17 (25.4)	1 (99.6)	85.3
T720	Surface/polymerase-RT	9 (13.4)	1 (99.6)	83.0
Y2131	Core	6 (9.0)	0 (100.0)	82.4
T2013	Core	5 (7.5)	0 (100.0)	82.1
K2048	Core	5 (7.5)	0 (100.0)	82.1
A2512	Polymerase-TP	5 (7.5)	0 (100.0)	82.1

HBV, hepatitis B virus; SVM, support vector machine; RT, reverse transcriptase; TP, terminal protein; % accuracy = (67 ×  % sensitivity + 280 ×  % specificity)/(67 + 280); Fisher’s exact test; value of is equivalent to 1.897 × 10⁻¹².