Stress-Adaptive Responses Associated with High-Level Carbapenem Resistance in KPC-Producing Klebsiella pneumoniae

Figure 1

Differential expression after 2 h and 8 h of lethal imipenem exposure. The proportion (%) of genes by ontological category showing increased or decreased expression (indicated by black arrows) after 2 h or 8 h of imipenem exposure for strains BR7 and BR21 (shown here with minimum threshold of 2-fold differential expression of imipenem-exposed compared to unexposed). Note that the proportion of stress-response genes is limited to those identified through initial annotation (see text for details).