Antimalarial Activity of Kaempferol and Its Combination with Chloroquine in Plasmodium berghei Infection in Mice
Antimalarial effect of kaempferol on PbANKA in a suppressive test. Groups of ICR mice (3 mice per group) were inoculated with 1x107 parasitized erythrocytes of PbANKA by IP injection. Two hours later, they were administered with 1, 10, and 20 mg/kg of kaempferol by oral gavage. Untreated control mice received 10 ml/kg of DW while positive control mice were given 10 mg/kg of CQ. A combination treatment of 10 mg/kg of CQ and 20 mg/kg of kaempferol was also administered. The treatment was carried out for 4 consecutive days (days 0-3). On day 4, parasitemia was determined by microscopic examination of Giemsa stained thin blood smears. P < 0.05, P < 0.01, and P < 0.001, compared to untreated control. UN; untreated control, 1KMF; 1 mg/kg of kaempferol, 10KMF; 10 mg/kg of kaempferol, 20KMF; 20 mg/kg of kaempferol, and 10CQ; 10 mg/kg of chloroquine. The results are expressed as mean ± SEM.
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