Antimalarial Activity of Kaempferol and Its Combination with Chloroquine in Plasmodium berghei Infection in Mice

Figure 1

Antimalarial effect of kaempferol on PbANKA in a suppressive test. Groups of ICR mice (3 mice per group) were inoculated with 1x10⁷ parasitized erythrocytes of PbANKA by IP injection. Two hours later, they were administered with 1, 10, and 20 mg/kg of kaempferol by oral gavage. Untreated control mice received 10 ml/kg of DW while positive control mice were given 10 mg/kg of CQ. A combination treatment of 10 mg/kg of CQ and 20 mg/kg of kaempferol was also administered. The treatment was carried out for 4 consecutive days (days 0-3). On day 4, parasitemia was determined by microscopic examination of Giemsa stained thin blood smears. P < 0.05, P < 0.01, and P < 0.001, compared to untreated control. UN; untreated control, 1KMF; 1 mg/kg of kaempferol, 10KMF; 10 mg/kg of kaempferol, 20KMF; 20 mg/kg of kaempferol, and 10CQ; 10 mg/kg of chloroquine. The results are expressed as mean ± SEM.