Antimalarial Activity of Kaempferol and Its Combination with Chloroquine in Plasmodium berghei Infection in Mice
Antimalarial effect of kaempferol on PbANKA in a curative test. Groups of ICR mice (3 mice per group) were inoculated with 1x107 PbANKA parasitized erythrocytes by IP injection for 4 days (days 0-3). Starting on day 4, the mice were given 1, 10, and 20 mg/kg of kaempferol by oral gavage for 4 consecutive days (day 4-7). Untreated and positive control mice received 10 ml/kg of DW and 10 mg/kg of CQ, respectively. A combination treatment of 10 mg/kg of CQ and 20 mg/kg of kaempferol was also administered. On day 8, parasitemia was determined by microscopic examination of Giemsa stained thin blood smears. P < 0.05, P < 0.01, and P < 0.001, compared to untreated control. UN; untreated control, 1KMF; 1 mg/kg of kaempferol, 10KMF; 10 mg/kg of kaempferol, 20KMF; 20 mg/kg of kaempferol, and 10CQ; 10 mg/kg of chloroquine. The results are expressed as mean ± SEM.
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